| ID | 14233 |
| Eprint ID | 14233
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| フルテキストURL | |
| タイトル（別表記） | Studies on immunoprophylactic effects of OK-432 and Ge-132 on methylcholanthrene-induced mouse sarcoma Part 1. Suppressive effects of OK-432 and Ge-132 with respect to timing of administration, and the role of natural killer cells
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| 著者 |
玉井 守
岡山大学医学部第二内科学教室
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| 抄録 | C3H mice were subcutaneously (s.c.) injected with a tumorigenic dose (1mg/mouse) of 3-methylcholanthrene (MC) and tumor development was observed for 18 weeks. OK-432 or Ge-132 was intraperitoneally administered either after MC injection (post-treatment) or both before and after MC injection (pre- and post-treatment). Pre- and post-treatment with OK-432 significantly inhibited the development of tumors from 10 to 12 weeks after MC injection as compared with a control group. In all of the groups, the incidence of tumors was 100 percent 18 weeks after MC injection. With respect to Ge-132, both post-treatment and pre- and post-treatment administration reduced tumor growth in a similar manner to pre- and post-treatment of OK-432. After pre-treatment with OK-432 or Ge-132 for two weeks, the percentage of large granular lymphocytes in peripheral blood and the natural killer activity of splenic cells in mice were increased. These results suggest that the immune status plays an important role in the defense mechanisms against chemically-induced tumors.
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| キーワード | Methylcholanthrene-induced sarcoma
OK-432
Ge-132
NK cell
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| 備考 | 原著
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| 発行日 | 1992-12
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 104巻
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| 号 | 11-12号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 1007
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| 終了ページ | 1014
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/104/11-12/104_11-12_1007/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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