検索結果 761 件
フルテキストURL | fulltext.pdf |
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著者 | Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi| |
発行日 | 2020-06-26 |
出版物タイトル | Molecular Therapy - Oncolytics |
巻 | 17巻 |
出版者 | Cell Press |
開始ページ | 107 |
終了ページ | 117 |
ISSN | 2372-7705 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 The Author(s). |
論文のバージョン | publisher |
PubMed ID | 32322667 |
DOI | 10.1016/j.omto.2020.03.016 |
Web of Science KeyUT | 000544101600010 |
関連URL | isVersionOf https://doi.org/10.1016/j.omto.2020.03.016 |
フルテキストURL | fulltext.pdf |
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著者 | Yoshida, Naoki| Kaito, Chikara| |
キーワード | RNA-Seq de novo assembly Transcriptome African bullfrog Pyxicephalus adspersus |
発行日 | 2020-06 |
出版物タイトル | Data in Brief |
巻 | 30巻 |
出版者 | Elsevier |
開始ページ | 105388 |
ISSN | 2352-3409 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 The Author(s). |
論文のバージョン | publisher |
PubMed ID | 32211462 |
DOI | 10.1016/j.dib.2020.105388 |
Web of Science KeyUT | 000541974300010 |
関連URL | isVersionOf https://doi.org/10.1016/j.dib.2020.105388 |
JaLCDOI | 10.18926/AMO/59958 |
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フルテキストURL | 74_3_245.pdf |
著者 | Yamamoto, Shumpei| Takayama, Hiroshi| Shimodate, Yuichi| Takezawa, Rio| Nishimura, Naoyuki| Doi, Akira| Mouri, Hirokazu| Matsueda, Kazuhiro| Mizuno, Motowo| Okada, Hiroyuki| |
抄録 | Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy. |
キーワード | vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-06 |
巻 | 74巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 245 |
終了ページ | 250 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32577023 |
Web of Science KeyUT | 000543363400008 |
NAID | 120006862799 |
JaLCDOI | 10.18926/AMO/59956 |
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フルテキストURL | 74_3_229.pdf |
著者 | Shibata, Kiyo| Hamasaki, Ichiro| Toshima, Shinji| Shimizu, Takehiro| Kono, Reika| Miyata, Manabu| Morisawa, Shin| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio| |
抄録 | The purpose of this study was to derive new formulas to provide an optimal surgical procedure and optimal amount of recession-resection (RR) surgery in intermittent exotropia (IXT) with a disparity in angle of deviation depending on the fixation distance. The records of 117 consecutive patients with IXT who underwent RR surgery between March 2008 and December 2011 at Okayama University Hospital were retrospectively examined. Multivariable linear regression analysis was performed using the observed corrective angle of deviation at distance or near fixation as the dependent variable, and amounts of lateral rectus muscle (LR) recession (mm) and medial rectus muscle (MR) resection, and age at surgery (years) as independent variables. Two simultaneous formulas were derived: corrective angle of deviation at distance fixation (°)=1.8×recession (mm)+1.6× resection (mm)+0.15×age (years)–6.6, and corrective angle at near fixation (°)=1.5×recession (mm)+1.7× resection (mm)+0.18×age (years)–3.8. Comparisons of coefficient values of the formulas between distance and near fixation revealed that LR recession was more affected by the corrective angle in distance than near fixation. MR resection was more affected at near than distance fixation. We found that our new formulas estimated the appropriate amount of unilateral RR surgery. |
キーワード | surgical amount intermittent exotropia recession and resection procedure strabismus surgery recurrent exotropia |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-06 |
巻 | 74巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 229 |
終了ページ | 236 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32577021 |
JaLCDOI | 10.18926/AMO/59951 |
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フルテキストURL | 74_3_209.pdf |
著者 | Matsui, Yusuke| Hiraki, Takao| Iguchi, Toshihiro| Sakurai, Jun| Uka, Mayu| Masaoka, Yoshihisa| Gobara, Hideo| Kanazawa, Susumu| |
抄録 | An aspiration-type semi-automatic cutting biopsy needle enables tissue cutting during application of negative pressure, which is expected to contribute to a larger amount of specimen. The aim of the present study was to evaluate this novel needle in a clinical setting. Patients who underwent image-guided percutaneous biopsy for lung or renal masses were enrolled. Cutting biopsy was performed with and without aspiration during each procedure. The specimens were weighed using an electronic scale. The weights were compared between specimens obtained with and without aspiration using a paired t-test. The data from 45 lung and 30 renal biopsy procedures were analyzed. In lung biopsy, the mean±standard deviation weights of specimens obtained with and without aspiration were 2.20±1.05 mg and 2.24±1.08 mg, respectively. In renal biopsy, the mean weights were 6.52±2.18 mg and 6.42±1.62 mg, respectively. The weights were not significantly different between specimens obtained with and without aspiration either in lung (p=0.799) or renal (p=0.789) biopsies. The application of negative pressure with the aspiration-type semi-automatic cutting biopsy needle did not contribute to an increase in the amount of the specimen obtained in lung and renal biopsies. |
キーワード | biopsy cutting needle aspiration clinical study |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-06 |
巻 | 74巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 209 |
終了ページ | 214 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32577018 |
Web of Science KeyUT | 000543363400004 |
NAID | 120006862793 |
JaLCDOI | 10.18926/AMO/59948 |
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フルテキストURL | 74_3_185.pdf |
著者 | Sano, Toshikazu| Ishigami, Shuta| Ito, Tatsuo| Sano, Shunji| |
抄録 | Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency. |
キーワード | heart disease stem cell myocardial regeneration |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-06 |
巻 | 74巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 185 |
終了ページ | 190 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32577015 |
Web of Science KeyUT | 000543363400001 |
NAID | 120006862790 |
フルテキストURL | fulltext.pdf |
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著者 | Luong, Minh N.| Shimada, Yasushi| Araki, Kazuyuki| Yoshiyama, Masahiro| Tagami, Junji| Sadr, Alireza| |
キーワード | dentin enamel optical coherence tomography radiograph receiver operating characteristic (ROC) analysis hidden caries dentino-enamel junction DEJ |
発行日 | 2020-03-17 |
出版物タイトル | Sensors |
巻 | 20巻 |
号 | 6号 |
出版者 | MDPI |
開始ページ | 1659 |
ISSN | 1424-8220 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by the authors. |
論文のバージョン | publisher |
PubMed ID | 32192069 |
DOI | 10.3390/s20061659 |
Web of Science KeyUT | 000529139700118 |
関連URL | isVersionOf https://doi.org/10.3390/s20061659 |
フルテキストURL | fulltext.pdf |
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著者 | Murase, Yurika| Kishimoto, Koji| Yoshida, Shoko| Kunisada, Yuki| Kadoya, Koichi| Ibaragi, Soichiro| Sasaki, Akira| |
発行日 | 2020-03-28 |
出版物タイトル | Journal of Surgical Case Reports |
号 | 3号 |
出版者 | Oxford University Press |
開始ページ | rjaa061 |
ISSN | 2042-8812 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2020. |
論文のバージョン | publisher |
PubMed ID | 32257103 |
DOI | 10.1093/jscr/rjaa061 |
Web of Science KeyUT | 000535663800034 |
関連URL | isVersionOf https://doi.org/10.1093/jscr/rjaa061 |
フルテキストURL | fulltext.pdf |
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著者 | Okusha, Yuka| Eguchi, Takanori| Tran, Manh T.| Sogawa, Chiharu| Yoshida, Kaya| Itagaki, Mami| Taha, Eman A.| Ono, Kisho| Aoyama, Eriko| Okamura, Hirohiko| Kozaki, Ken-Ichi| Calderwood, Stuart K.| Takigawa, Masaharu| Okamoto, Kuniaki| |
キーワード | matrix metalloproteinase moonlighting metalloproteinase (MMP) protein moonlighting transcription factor extracellular vesicles oncosome genome editing CRISPR cellular communication network factor CCN2/CTGF |
発行日 | 2020-04-04 |
出版物タイトル | Cancers |
巻 | 12巻 |
号 | 4号 |
出版者 | MDPI |
開始ページ | 881 |
ISSN | 2072-6694 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by the authors. |
論文のバージョン | publisher |
PubMed ID | 32260433 |
DOI | 10.3390/cancers12040881 |
Web of Science KeyUT | 000535587400110 |
関連URL | isVersionOf https://doi.org/10.3390/cancers12040881 |
フルテキストURL | fulltext.pdf |
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著者 | Yoshida, Takashi| Yasui, Norihisa| Kusakabe, Yuko| Ito, Chiaki| Akamatsu, Miki| Yamashita, Atsuko| |
発行日 | 2019-10-04 |
出版物タイトル | PLOS ONE |
巻 | 14巻 |
号 | 10号 |
出版者 | Public Library of Science |
開始ページ | e0218909 |
ISSN | 1932-6203 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2019 Yoshida et al. |
論文のバージョン | publisher |
PubMed ID | 31584955 |
DOI | 10.1371/journal.pone.0218909 |
Web of Science KeyUT | 000532407600003 |
関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0218909 |
フルテキストURL | fulltext.pdf |
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著者 | Yoshida, Yuichi| Nishimoto, Toshi| |
発行日 | 2020 |
出版物タイトル | The Horticulture Journal |
巻 | 89巻 |
号 | 2号 |
出版者 | The Japanese Society for Horticultural Science |
開始ページ | 87 |
終了ページ | 95 |
ISSN | 21890102 |
NCID | AA12708073 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | publisher |
NAID | 130007829010 |
DOI | 10.2503/hortj.UTD-R010 |
Web of Science KeyUT | 000526056300002 |
関連URL | isVersionOf https://doi.org/10.2503/hortj.UTD-R010 |
フルテキストURL | fulltext.pdf |
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著者 | Indeche, Annah Khatenje| Yoshida, Yuichi| Goto, Tanjuro| Yasuba, Ken-ichiro| Tanaka, Yoshiyuki| |
発行日 | 2020 |
出版物タイトル | The Horticulture Journal |
巻 | 89巻 |
号 | 1号 |
出版者 | The Japanese Society for Horticultural Science |
開始ページ | 22 |
終了ページ | 29 |
ISSN | 21890102 |
NCID | AA12708073 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | publisher |
NAID | 130007788542 |
DOI | 10.2503/hortj.UTD-079 |
Web of Science KeyUT | 000509223100003 |
関連URL | isVersionOf ttps://doi.org/10.2503/hortj.UTD-079 |
フルテキストURL | fulltext.pdf |
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著者 | Matsumoto, Naohisa| Matsusaki, Takashi| Hiroi, Kazumasa| Kaku, Ryuji| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi| |
備考 | 11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)| |
発行日 | 2020-03-31 |
出版物タイトル | Transplantation Proceedings |
巻 | 52巻 |
号 | 2号 |
出版者 | Elsevier |
開始ページ | 630 |
終了ページ | 633 |
ISSN | 00411345 |
NCID | AA00868957 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 The Authors. Published by Elsevier Inc. |
論文のバージョン | publisher |
PubMed ID | 32029317 |
DOI | 10.1016/j.transproceed.2019.11.032 |
Web of Science KeyUT | 000518473000059 |
関連URL | isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032 |
フルテキストURL | fulltext.pdf |
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著者 | Yoshida, Ryusuke| Takai, Shingo| Sanematsu, Keisuke| Margolskee, Robert F.| Shigemura, Noriatsu| Ninomiya, Yuzo| |
キーワード | bitter antagonists bitter receptor breadth of responsiveness taste coding transgenic mouse |
発行日 | 2018-01-15 |
出版物タイトル | Neuroscience |
巻 | 369巻 |
出版者 | Elsevier |
開始ページ | 29 |
終了ページ | 39 |
ISSN | 0306-4522 |
NCID | AA0075489X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 29113930 |
DOI | 10.1016/j.neuroscience.2017.10.047 |
Web of Science KeyUT | 000419475500003 |
関連URL | isVersionOf https://doi.org/10.1016/j.neuroscience.2017.10.047 |
フルテキストURL | fulltext.pdf |
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著者 | Masamoto, Michimasa| Mitoh, Yoshihiro| Kobashi, Motoi| Shigemura, Noriatsu| Yoshida, Ryusuke| |
キーワード | bitter coding bitter inhibitor gustatory response species difference taste perception |
発行日 | 2020-05-13 |
出版物タイトル | Neuroscience Letters |
出版者 | Elsevier |
開始ページ | 135041 |
ISSN | 0304-3940 |
NCID | AA00754925 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 32413538 |
DOI | 10.1016/j.neulet.2020.135041 |
関連URL | isVersionOf https://doi.org/10.1016/j.neulet.2020.135041 |
フルテキストURL | K0006148_abstract_review.pdf K0006148_summary.pdf K0006148_fulltext.pdf |
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著者 | 吉田 沙織| |
発行日 | 2020-03-25 |
資料タイプ | 学位論文 |
学位授与番号 | 甲第6148号 |
学位授与年月日 | 2020-03-25 |
学位・専攻分野 | 博士(歯学) |
授与大学 | 岡山大学 |
言語 | 英語 |
フルテキストURL | fulltext.pdf |
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著者 | Katayama, Norihisa| Sato, Shuhei| Katsui, Kuniaki| Takemoto, Mitsuhiro| Tsuda, Toshihide| Yoshida, Atsushi| Morito, Tsuneharu| Nakagawa, Tomio| Mizutani, Akifumi| Waki, Takahiro| Niiya, Harutaka| Kanazawa, Susumu| |
キーワード | Breast cancer Breast-conserving surgery Radiotherapy Radiation-induced BOOP syndrome Endocrine therapy |
発行日 | 2009-03-15 |
出版物タイトル | International journal of radiation oncology, biology, physics |
巻 | 73巻 |
号 | 4号 |
出版者 | Elsevier |
開始ページ | 1049 |
終了ページ | 1054 |
ISSN | 0360-3016 |
NCID | AA00680920 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 18755559 |
DOI | 10.1016/j.ijrobp.2008.05.050 |
Web of Science KeyUT | 000264257400014 |
関連URL | isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050 |
JaLCDOI | 10.18926/AMO/58277 |
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フルテキストURL | 74_2_171.pdf |
著者 | Okita, Atsushi| Yoshida, Osamu| Murakami, Masakazu| |
抄録 | A 76-year-old Japanese man was transferred to our hospital to undergo rehabilitation after traffic accident-related injuries. Seven days post-admission, he presented with abdominal pain and an 8-cm lump in the right inguinal region. He was diagnosed with an incarcerated inguinal hernia and underwent elective surgery the day after manual reduction. He had a normal vermiform appendix which was observed to have adhered to the right indirect hernia sac. An appendectomy and hernia repair using lightweight mesh were performed. We discuss the surgical management of this rare incarcerated Amyand’s hernia and the relevant literature. |
キーワード | Amyand’s hernia incarcerated inguinal hernia appendectomy |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-04 |
巻 | 74巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 171 |
終了ページ | 174 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32341593 |
Web of Science KeyUT | 000528278500012 |
NAID | 120006839456 |
JaLCDOI | 10.18926/AMO/58273 |
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フルテキストURL | 74_2_145.pdf |
著者 | Otsuki, Hideo| Yamasaki, Tomoya| Hori, Shunsuke| Aoki, Hiroshi| Kosaka, Takeo| Uehara, Shinya| Fujio, Kei| |
抄録 | To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent. |
キーワード | stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-04 |
巻 | 74巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 145 |
終了ページ | 150 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32341589 |
Web of Science KeyUT | 000528278500008 |
NAID | 120006839452 |
JaLCDOI | 10.18926/AMO/58267 |
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フルテキストURL | 74_2_103.pdf |
著者 | Kawada, Yasumasa| Kubo, Toru| Baba, Yuichi| Hirota, Takayoshi| Tanioka, Katsutoshi| Yamasaki, Naohito| Kitaoka, Hiroaki| |
抄録 | This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment. |
キーワード | hypertension dyslipidemia single-pill therapy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-04 |
巻 | 74巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 103 |
終了ページ | 108 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32341583 |
Web of Science KeyUT | 000528278500002 |
NAID | 120006839446 |