検索結果 1721 件
| フルテキストURL | K0006535_abstract_review.pdf K0006535_fulltext.pdf K0006535_summary.pdf |
|---|---|
| 著者 | 西村 健| |
| 発行日 | 2022-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6535号 |
| 学位授与年月日 | 2022-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2020 Wolters Kluwer Health, Inc. |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Hasegawa, Kou| Otsuka, Fumio| |
| 発行日 | 2022-04-14 |
| 出版物タイトル | PLOS ONE |
| 巻 | 17巻 |
| 号 | 4号 |
| 出版者 | Public Library Science |
| 開始ページ | e0266853 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Hagiya et al. |
| 論文のバージョン | publisher |
| PubMed ID | 35421155 |
| DOI | 10.1371/journal.pone.0266853 |
| Web of Science KeyUT | 000795453600071 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0266853 |
| フルテキストURL | fulltext20220527-2.pdf |
|---|---|
| 著者 | Nguyen, Tai Truong| Kitagawa, Hiroshi| Pineda‐Velasco, Ivan| Nakamura, Eizo| |
| キーワード | subduction zone volcanism mantle basalt slab |
| 備考 | Nguyen, T. T., Kitagawa, H., Pineda-Velasco, I., & Nakamura, E. (2020). Feedback of slab distortion on volcanic arc evolution: Geochemical perspective from late Cenozoic volcanism in SW Japan. Journal of Geophysical Research: Solid Earth, 125, e2019JB019143. https://doi.org/10.1029/2019JB019143. To view the published open abstract, go to https://doi.org/10.1029/2019jb019143| |
| 発行日 | 2020-10 |
| 出版物タイトル | Journal of Geophysical Research: Solid Earth |
| 巻 | 125巻 |
| 号 | 10号 |
| 出版者 | American Geophysical Union (AGU) |
| 開始ページ | e2019JB019143 |
| ISSN | 2169-9313 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2020. American Geophysical Union. All Rights Reserved. |
| 論文のバージョン | publisher |
| DOI | 10.1029/2019jb019143 |
| Web of Science KeyUT | 000604458900037 |
| 関連URL | isVersionOf https://doi.org/10.1029/2019jb019143 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Namba, Kei| Suzawa, Ken| Shien, Kazuhiko| Miura, Akihiro| Takahashi, Yuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Tomida, Shuta| Tanaka, Shin| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi| |
| 発行日 | 2022-05-04 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 7297 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35508484 |
| DOI | 10.1038/s41598-022-11064-4 |
| Web of Science KeyUT | 000790941900040 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-11064-4 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Kitahara, Kei| Debnath, Anusuya| Ohno, Ayumu| Okamoto, Keinosuke| Miyoshi, Shin-Ichi| |
| キーワード | cholera outbreak water supply open defecation sewage household food close contact behavioral changes India |
| 発行日 | 2022-05-08 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 9号 |
| 出版者 | MDPI |
| 開始ページ | 5738 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35565133 |
| DOI | 10.3390/ijerph19095738 |
| Web of Science KeyUT | 000794591500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph19095738 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sukegawa, Shintaro| Fujimura, Ai| Taguchi, Akira| Yamamoto, Norio| Kitamura, Akira| Goto, Ryosuke| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| 発行日 | 2022-04-12 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 6088 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35413983 |
| DOI | 10.1038/s41598-022-10150-x |
| Web of Science KeyUT | 000782202600026 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-10150-x |
| フルテキストURL | fulltext20220509-1.pdf Supporting_Information20220509-1.pdf |
|---|---|
| 著者 | Ohtsuka, Satomi| Okumura, Taisei| Τabuchi, Yuna| Miyagawa, Tomoyuki| Kanayama, Naoki| Magari, Masaki| Hatano, Naoya| Sakagami, Hiroyuki| Suizu, Futoshi| Ishikawa, Teruhiko| Tokumitsu, Hiroshi| |
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biochem.1c00796| |
| 発行日 | 2022-03-11 |
| 出版物タイトル | Biochemistry |
| 巻 | 61巻 |
| 号 | 7号 |
| 出版者 | American Chemical Society (ACS) |
| 開始ページ | 545 |
| 終了ページ | 553 |
| ISSN | 0006-2960 |
| NCID | AA00564599 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright © 2022 American Chemical Society |
| 論文のバージョン | author |
| DOI | 10.1021/acs.biochem.1c00796 |
| Web of Science KeyUT | 000783678600007 |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.biochem.1c00796 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takahashi, Misa| Hagiya, Hideharu| Higashionna, Tsukasa| Nakano, Yasuhiro| Sato, Kota| Haruki, Yuto| Haruki, Mai| Honda, Hiroyuki| Ogawa, Hiroko| Ueda, Keigo| Otsuka, Fumio| |
| 発行日 | 2022-04-08 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 5921 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35396378 |
| DOI | 10.1038/s41598-022-09946-8 |
| Web of Science KeyUT | 000781895600057 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-09946-8 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| フルテキストURL | 76_2_217.pdf |
| 著者 | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| 抄録 | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| キーワード | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 217 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| フルテキストURL | 76_2_203.pdf |
| 著者 | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| キーワード | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| JaLCDOI | 10.18926/AMO/63414 |
|---|---|
| フルテキストURL | 76_2_195.pdf |
| 著者 | Inoue, Shinichiro| Maeda, Isseki| Ogawa, Asao| Yoshiuchi, Kazuhiro| Terada, Seishi| Yamada, Norihito| |
| 抄録 | The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event. |
| キーワード | delirium cancer perospirone risperidone |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 195 |
| 終了ページ | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503448 |
| Web of Science KeyUT | 000792291900002 |
| JaLCDOI | 10.18926/AMO/63413 |
|---|---|
| フルテキストURL | 76_2_187.pdf |
| 著者 | Ren, Wanxu| Matsusaki, Takashi| Abugri Osman Bright| Morimatsu, Hiroshi| |
| 抄録 | Remifentanil is an ultra-short-acting opioid that sometimes causes opioid-induced hyperalgesia, which has led to controversy regarding the association between intraoperative remifentanil administration and postoperative pain. This study aimed to assess the effects of the intraoperative remifentanil dose on postoperative pain. Patients undergoing esophageal, gastric/hepatobiliary, or intestinal/colon surgery and using postoperative patient-controlled epidural analgesia were analyzed. The patients were divided into two groups based on the average intraoperative remifentanil dose (high-dose remifentanil [HR] group: ≥0.1 μg/kg/min; low-dose remifentanil [LR] group: <0.1 μg/kg/min). In all, 406 patients met the inclusion criteria. A significant difference in the average dose of remifentanil was seen between the groups during the anesthesia period (0.14±0.05 vs. 0.07±0.02 μg/kg/min). However, no significant difference was seen in pre- or intraoperative patient characteristics. Numerical rating scale (NRS) scores on postoperative day 1 were similar between the groups (HR: 1.7±2.0; LR: 1.7±2.0; p=0.74). The incidence of poor pain control (NRS > 3/10) was also similar between the groups (HR: 14%; LR: 16%; p=0.57). Older age (> 60 years) and type of surgery (esophageal surgery) were associated with worse postoperative NRS scores. No significant association was seen between the intraoperative remifentanil dose and postoperative NRS scores following thoracoabdominal surgery with postoperative epidural pain management. |
| キーワード | high-dose remifentanil postoperative numerical rating scale type of surgery epidural block |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 187 |
| 終了ページ | 193 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503447 |
| Web of Science KeyUT | 000792291900001 |
| JaLCDOI | 10.18926/AMO/63412 |
|---|---|
| フルテキストURL | 76_2_179.pdf |
| 著者 | Higashi, Tomoko| Murata, Naomichi| Fujimoto, Maki| Miyake, Saki| Egusa, Masahiko| Higuchi, Hitoshi| Maeda, Shigeru| Miyawaki, Takuya| |
| 抄録 | Patients with neurodegenerative diseases are at an increased risk of dysphagia and aspiration pneumonia. In this study, we examined whether ingestion of capsaicin prior to swallowing changes the temporal dynamics of swallowing in such patients. In a crossover, randomized controlled trial, 29 patients with neurodegenerative diseases were given a soluble wafer containing 1.5 μg capsaicin or an identical placebo 20 min prior to testing. For evaluation with video fluoroscopy (VF), patients consumed a barium-containing liquid plus thickening material. The durations of the latency, elevating and recovery periods of the hyoid were assessed from VF. Overall, no significant differences were observed in the duration of each period between capsaicin and placebo treatments. However, reductions in the latency and elevating periods were positively correlated with baseline durations. In subgroup analyses, that correlation was observed in patents with amyotrophic lateral sclerosis (ALS) but not in patients with Parkinson’s disease. The consumption of wafer paper containing capsaicin before the intake of food may be effective in patients with dysphagia related with certain neurodegenerative diseases, particularly ALS patients. Further studies will be needed to validate this finding. |
| キーワード | deglutition disorder fluoroscopy neurodegenerative diseases amyotrophic lateral sclerosis Parkinson disease |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 179 |
| 終了ページ | 186 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503446 |
| Web of Science KeyUT | 000792374900010 |
| JaLCDOI | 10.18926/AMO/63408 |
|---|---|
| フルテキストURL | 76_2_145.pdf |
| 著者 | Qin, Yi| Liu, Linlin| Zhu, Fanghui| Lu, Huazhen| Huang, Mingliu| |
| 抄録 | With rapidly aging populations, family care functions can become weakened, and community health services often lack unified standards. A standardized and professional community home-based long-term care model (CHLCM) for the elderly is urgently needed in many regions of China and in other countries. Here, we explored the indicators of the need for a CHLCM among elderly individuals, and we constructed a CHLCM. We created and distributed a questionnaire regarding the requirement of long-term care services, based on a literature review. The two-rounds Delphi method was used, involving 20 experts who were randomly selected from among the medical universities, community health service centers, and nursing homes in Nanning, Guangxi, China. The experts’ enthusiasm rates in the questionnaire’s two rounds were 95% and 100%, respectively. The authentic coefficient of the experts’ consulting was 0.857, and that of the experts’ academic level was 0.835; the judgement coefficient was 0.880 and the familiar coefficient was 0.855. The CHLCM includes service content and an evaluation. The coordination coefficients for the two primary, eight secondary, and 29 tertiary indicators were 0.200, 0.386, and 0.184, respectively (p<0.05). The experts’ enthusiasm and authority were high. The coordination of the experts’ agreement was sufficient, and the analysis results were reliable. The CHLCM includes 29 items that provide a foundation and references for the formulation of concrete indicators and subsequent research. |
| キーワード | community home-based long-term care elderly indicator system |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 145 |
| 終了ページ | 154 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503442 |
| Web of Science KeyUT | 000792374900006 |
| JaLCDOI | 10.18926/AMO/63407 |
|---|---|
| フルテキストURL | 76_2_137.pdf |
| 著者 | Tsukahara, Masaru| So, Ryuhei| Yada, Yuji| Kodama, Masafumi| Kishi, Yoshiki| Yamada, Norihito| |
| 抄録 | Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients. |
| キーワード | Asian clozapine schizophrenia smoking |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503441 |
| Web of Science KeyUT | 000792374900005 |
| JaLCDOI | 10.18926/AMO/63405 |
|---|---|
| フルテキストURL | 76_2_121.pdf |
| 著者 | Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Kamatsuki, Yusuke| Nakata, Eiji| Tetsunaga, Tomonori| Yamane, Kentaro| Ozaki, Toshifumi| |
| 抄録 | Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK. |
| キーワード | medial meniscus posterior root tear subchondral insufficiency fracture bone marrow edema meniscus extrusion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 121 |
| 終了ページ | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503439 |
| Web of Science KeyUT | 000792374900003 |
| JaLCDOI | 10.18926/AMO/63403 |
|---|---|
| フルテキストURL | 76_2_105.pdf |
| 著者 | Takaoka, Megumi| Ohsumi, Shozo| Ikejiri, Haruka| Shidahara, Tomohiro| Miyoshi, Yuichiro| Takahashi, Mina| Takashima, Seiki| Aogi, Kenjiro| |
| 抄録 | Cases of breast cancer metastasis after achieving a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) are sometimes encountered in clinical practice. We investigated the prognostic factors for pCR in patients with breast cancer after NAC. This retrospective cohort study included patients with localized breast cancer who underwent NAC followed by surgery between 2004 and 2020 and achieved a pCR. The associations between clinical factors and distant metastasis-free survival rate were statistically analyzed. We analyzed data for 127 patients. Twelve patients (9.4%) had distant metastases, and seven (5.5%) died. For estrogen receptor (ER)-positive patients, the distant metastasis-free survival rate was 94.6% for both 5 and 8 years. In contrast, ER-negative patients had a distant metastasis-free survival rate of 87.6% and 85.4% for 5 and 8 years (p=0.094), respectively. In cT0-2 patients, the distant metastasis-free survival rate was 92.4% for 5 years and 90.5% for 8 years, whereas in cT3-4 patients, the distant metastasis-free survival rate was 83.5% for 5 years and 83.5% for 8 years (p=0.301). This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis. |
| キーワード | breast carcinoma neoadjuvant therapy prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 105 |
| 終了ページ | 111 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503437 |
| Web of Science KeyUT | 000792374900001 |
| フルテキストURL | fulltext20220413-6-2.pdf |
|---|---|
| 著者 | Sato, Yukiyo| Shahi, Sabitree| Telengech, Paul| Hisano, Sakae| Cornejo, Carolina| Rigling, Daniel| Kondo, Hideki| Suzuki, Nobuhiro| |
| キーワード | Splipalmivirus Capsidless RNA virus Cryphonectria naterciae Narnavirus Fungal virus Mycovirus |
| 備考 | © 2021 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.virusres.2021.198606] .| |
| 発行日 | 2022-01 |
| 出版物タイトル | Virus Research |
| 巻 | 307巻 |
| 号 | 2号 |
| 出版者 | Elsevier BV |
| 開始ページ | 198606 |
| ISSN | 0168-1702 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 34688782 |
| DOI | 10.1016/j.virusres.2021.198606 |
| Web of Science KeyUT | 000767885500002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.virusres.2021.198606 |
| JaLCDOI | 10.18926/63359 |
|---|---|
| タイトル（別表記） | Issues and improvements in new first-year students’ online classes under COVID-19 pandemic: A report on "Introduction to Okayama University", a university-wide guidance course |
| フルテキストURL | biess_6_206_217_v2.pdf |
| 著者 | 宇塚 万里子| 稲森 岳央| |
| 抄録 | 新型コロナウィルス感染症の影響を受け、新入生対象の必須科目「岡山大学入門講座」は、2020年度および2021年度ともにオンラインでの実施となった。本研究では、2020年度の経験から明らかになった課題をもとに、どのような改善策が効果的なのかを明らかにすることを試みた。学生側の主な課題は、①タイムマネジメントカの弱さ、②オンラインによる孤独感、③IT リテラシーの低さであった。これらに対応するため、2021年度は①週ごとに課題提出日を指定、②対面（ライブ）授業の導入、③より分かりやすいMoodleページの作成を行った。また、双方向感を強くするために、課題に対する早いフィードバック、学修が遅れている学生へのリマインド、素早い質間対応等を行った。その結果、授業評価アンケートの満足度が向上が見られた。 |
| キーワード | オンライン授業 学習態度 授業評価 満足度 学生支援 |
| 出版物タイトル | 岡山大学全学教育・学生支援機構教育研究紀要 |
| 発行日 | 2021-12-30 |
| 巻 | 6巻 |
| 開始ページ | 206 |
| 終了ページ | 217 |
| ISSN | 2432-9665 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Norio| Mitsuhashi, Toshiharu| Tsuchihashi, Yuuki| Yorifuji, Takashi| |
| キーワード | Tokyo 2020 Olympic and Paralympic Games COVID-19 pandemic synthetic control method causal effect ecological study |
| 発行日 | 2022-02-03 |
| 出版物タイトル | Journal Of Personalized Medicine |
| 巻 | 12巻 |
| 号 | 2号 |
| 出版者 | MDPI |
| 開始ページ | 209 |
| ISSN | 2075-4426 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35207697 |
| DOI | 10.3390/jpm12020209 |
| Web of Science KeyUT | 000769713400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jpm12020209 |