癌毒素の骨髄に及ぼす影響 第1編 骨髄灌流試験による癌毒素の作用に関する実験的研究

Comparison was made between the blood pictures of nutritional vein in the femur and of femoral artery following irrigation of fresh extract of cancerous tissue obtained from stomach cancer. Although, no significant fluctuations were encountered between them in short period after irrigation, it was observed that a marked decrease (27% -30% ) of red blood cells in the nutritional vein after more than three succeeding irrigations daily. In the other hand, a slight decrease (12% -13% ) of red blood cells was observed in femoral artery blood. The fact shows that the cancer toxin directly affected bone marrow gains anemia-producing action after circulating the body, which is followed by so-called blood cell "Sperre" in bone marrow. Red cells decrease noticeably in nutritional vein of bone marrow by irrigation with sera obtained from stomach cancer patients, showing a peak of decrease one to two hours and restores to preexperimental level after six to eight hours. The same result is noticeable regarding to the leucocytes but its Schilling differentiation is not significantly changed. Serum of healthy man does not produce above-described effects on bone marrow by irrigation. Serum of anemic rabbit produced experimentally by successive injection of cancer extract decreases red cells in the nutritional vein following irrigation into normal rabbit marrow.