Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Yamamoto, Shusei; Sato, Ikumi; Fujii, Moe; Kakimoto, Mai; Honma, Koki; Akiyama, Natsumi; Sakai, Miku; Fukuhama, Natsuki; Kumazaki, Shota; Hirohata, Satoshi; Kitamori, Kazuya; Yamori, Yukio; Watanabe, Shogo

ID	64358
JaLCDOI	10.18926/AMO/64358
フルテキストURL	77_1_29.pdf 93.8 MB
著者	Yamamoto, Shusei Academic Field of Health Sciences, Okayama University Sato, Ikumi Department of Medical Technology, Graduate School of Health Sciences, Okayama University Fujii, Moe Department of Medical Technology, Graduate School of Health Sciences, Okayama University Kakimoto, Mai Department of Medical Technology, Graduate School of Health Sciences, Okayama University Honma, Koki Department of Medical Technology, Graduate School of Health Sciences, Okayama University Akiyama, Natsumi Department of Medical Technology, Faculty of Health Sciences, Okayama University Sakai, Miku Department of Medical Technology, Faculty of Health Sciences, Okayama University Fukuhama, Natsuki Department of Medical Technology, Faculty of Health Sciences, Okayama University Kumazaki, Shota Department of Medical Technology, Graduate School of Health Sciences, Okayama University Hirohata, Satoshi Academic Field of Health Sciences, Okayama University ORCID Kaken ID publons researchmap Kitamori, Kazuya College of Human Life and Environment, Kinjo Gakuin University Yamori, Yukio Institute for World Health Development, Mukogawa Women's University Watanabe, Shogo Academic Field of Health Sciences, Okayama University
抄録	The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.
キーワード	SHRSP5/Dmc nonalcoholic steatohepatitis cardiovascular disease glycine-conjugated bile acids unconjugated bile acids
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	36
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849143
Web of Science KeyUT	000953019200001