サルファ剤の皮膚内代謝の研究

It is a well-known fact that at the time of administration of sulfadrug to normal subjects, its metabolism is done mostly in liver and kidney. From my experimental results, I confirmed the exsistence of autonomous sulfadrug metabolism in the skin like liver and kidney. Results: 1) After oral administration of p-aminobenzoic acid (PABA) to rabbit, acetyl-PABA was measured quantitativly in the skin and other 10 organs, and the ratio of acetylation in the skin showed the smallest level of all 11 organs. 2) In injured and normal skin, each ratio of acetylation was almost the same. 3) Quantitative analysis of gurucuronic acid in normal skin showed 0.98 mg/100g by modified Fishman's method. 4) Qualitative experiments using paper chromatography and thin layer chromatography showed that metabolized sulfadrug (Sulfathiazole) was identified in spots Rf 0.55, 0.09, after incubating Sulfathiazole in the skin homogenate 2 hrs., at 37°C. Then, both metabolites seem to be N4-acetylsulfathiazole and Sulfathiazole-N4-gurucosidouronate

学位番号 乙第207号