検索結果 1313 件
| JaLCDOI | 10.18926/AMO/62820 |
|---|---|
| フルテキストURL | 75_6_763.pdf |
| 著者 | Iwata, Takehiro| Sadahira, Takuya| Maruyama, Yuki| Sekito, Takanori| Yoshinaga, Kasumi| Watari, Shogo| Nagao, Kentaro| Kawada, Tatsushi| Tominaga, Yusuke| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Ishii, Ayano| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| Wada, Koichiro| |
| 抄録 | The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants. |
| キーワード | genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 763 |
| 終了ページ | 766 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955548 |
| Web of Science KeyUT | 000735319800006 |
| NAID | 120007180272 |
| JaLCDOI | 10.18926/AMO/62819 |
|---|---|
| フルテキストURL | 75_6_759.pdf |
| 著者 | Shimizu, Dai| Yamamoto, Hiromasa| Shien, Kazuhiko| Taniguchi, Kohei| Miyoshi, Kentaroh| Namba, Kei| Mesaki, Kumi| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi| |
| 抄録 | Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer. |
| キーワード | non-small cell lung cancer somatic mutations pulmonary adenocarcinoma with enteric differentiation non-V600E BRAF mutation next-generation sequencing |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 759 |
| 終了ページ | 762 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955547 |
| Web of Science KeyUT | 000735319800005 |
| NAID | 120007180273 |
| JaLCDOI | 10.18926/AMO/62816 |
|---|---|
| フルテキストURL | 75_6_745.pdf |
| 著者 | Hayata, Kei| Mishima, Sakurako| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Ogawa, Chikako| Masuyama, Hisashi| |
| 抄録 | NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results. |
| キーワード | NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 745 |
| 終了ページ | 750 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955544 |
| Web of Science KeyUT | 000735319800002 |
| NAID | 120007180276 |
| JaLCDOI | 10.18926/AMO/62812 |
|---|---|
| フルテキストURL | 75_6_719.pdf |
| 著者 | Uehara, Shinya| Fujio, Kei| Yamasaki, Tomoya| Otsuki, Hideo| |
| 抄録 | Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis. |
| キーワード | acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 719 |
| 終了ページ | 724 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955540 |
| Web of Science KeyUT | 000735297900008 |
| NAID | 120007180280 |
| JaLCDOI | 10.18926/AMO/62810 |
|---|---|
| フルテキストURL | 75_6_705.pdf |
| 著者 | Iwata, Takehiro| Maruyama, Yuki| Kawada, Tatsushi| Sadahira, Takuya| Katayama, Satoshi| Takamoto, Atsushi| Sako, Tomoko| Wada, Koichiro| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| 抄録 | Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients. |
| キーワード | testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 711 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955538 |
| Web of Science KeyUT | 000735297900006 |
| NAID | 120007180282 |
| JaLCDOI | 10.18926/AMO/62808 |
|---|---|
| フルテキストURL | 75_6_691.pdf |
| 著者 | Kato, Yuji| Hayashi, Takeshi| Kato, Ritsushi| Uchino, Akira| Takao, Masaki| Takahashi, Shinichi| |
| 抄録 | Although diagnostic and therapeutic strategies for acute stroke patients in Japan depend largely on magnetic resonance imaging (MRI), patients with cardiac implantable electronic devices (CIED) must still rely on com-puted tomography (CT). We retrospectively analyzed clinical and neuroimaging data of ischemic stroke patients with CIED treated at our hospital. Forty-five patients were enrolled in the study. Patients were divided into two groups according to whether corresponding lesions were detected (group A, n = 21) or not detected (group B, n = 24) by the first brain CT. We also evaluated in detail the clinical courses of patients who arrived at hospital within therapeutic time windows for recanalization therapy. Negative fresh infarct in the first CT was associated, though not significantly, with early onset-to-arrival time and subcortical white matter infarction. Five patients did not undergo recanalization therapy because their families did not agree to the procedure. The reasons for their lack of consent included inadequate information about the safety and efficacy of recanalization therapy because MRI could not be performed. Our study confirmed delayed detection of the corresponding lesion and undertreatment for acute stroke in patients with CIED. |
| キーワード | stroke cardiac implantable electronic device computed tomography magnetic resonance imaging |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 691 |
| 終了ページ | 697 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955536 |
| Web of Science KeyUT | 000735297900004 |
| NAID | 120007180284 |
| JaLCDOI | 10.18926/AMO/62807 |
|---|---|
| フルテキストURL | 75_6_685.pdf |
| 著者 | Yamashita, Mampei| Kuroki, Tamotsu| Hamada, Takashi| Hirayama, Takanori| Tokunaga, Takayuki| Yamanouchi, Kosho| Takeshita, Hiroaki| Maeda, Shigeto| |
| 抄録 | Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive imaging technique that provides high-quality visualization of the biliary tree, including the gallbladder. This study aimed to evaluate the useful-ness of preoperative MRCP for acute cholecystitis in predicting technical difficulties during laparoscopic chole-cystectomy (LC). A total of 168 patients who underwent LC with preoperative MRCP were enrolled in this study. Patients were divided into two groups according to preoperative MRCP findings: the visualized group (n = 126), in which the entire gallbladder could be visualized; and the non-visualized group (n = 42), in which the entire gallbladder could not be visualized. The perioperative characteristics and postoperative complica-tions of the two groups were retrospectively analyzed. Operation time was longer in the non-visualized group (median 101.5 vs. 143.5 min; p < 0.001). The non-visualized group had significantly more intraoperative blood loss than the visualized group (median 5 vs. 10 g; p = 0.05). The rate of conversion to open cholecystectomy was significantly higher in the non-visualized group (1.6 vs. 9.5%; p = 0.03). In conclusion, patients in the non- visualized group showed higher difficulty in performance of LC. Our MRCP-based classification is a simple and effective means of predicting difficulties in performing LC for acute cholecystitis. |
| キーワード | laparoscopic cholecystectomy magnetic resonance cholangiopancreatography acute cholecystitis gallbladder disease non-invasive imaging |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 685 |
| 終了ページ | 689 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955535 |
| Web of Science KeyUT | 000735297900003 |
| NAID | 120007180285 |
| JaLCDOI | 10.18926/AMO/62806 |
|---|---|
| フルテキストURL | 75_6_677.pdf |
| 著者 | Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy. |
| キーワード | endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 677 |
| 終了ページ | 684 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955534 |
| Web of Science KeyUT | 000735297900002 |
| NAID | 120007180286 |
| JaLCDOI | 10.18926/AMO/62782 |
|---|---|
| フルテキストURL | 75_5_663.pdf |
| 著者 | Sadahira, Takuya| Maruyama, Yuki| Hiyama, Yoshiki| Kitano, Hiroyuki| Yamada, Hiroki| Goto, Takayuki| Kondo, Tsubasa| Shigemura, Katsumi| Mitsui, Yosuke| Iwata, Takehiro| Edamura, Kohei| Araki, Motoo| Watanabe, Masami| Takenaka, Tadasu| Teishima, Jun| Miyata, Yasuyoshi| Ishikawa, Kiyohito| Takaoka, Ei-Ichiro| Miyazaki, Jun| Takahashi, Satoshi| Masumori, Naoya| Kiyota, Hiroshi| Fujisawa, Masato| Yamamoto, Shingo| Sakuma, Takafumi| Kusumi, Norihiro| Ichikawa, Takaharu| Watanabe, Toyohiko| Nasu, Yoshitsugu| Tsugawa, Masaya| Nasu, Yasutomo| Wada, Koichiro| |
| 抄録 | The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. |
| キーワード | antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 663 |
| 終了ページ | 667 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703052 |
| Web of Science KeyUT | 000711568400007 |
| NAID | 120007166667 |
| JaLCDOI | 10.18926/AMO/62776 |
|---|---|
| フルテキストURL | 75_5_631.pdf |
| 著者 | Yamamoto, Koichiro| Omura, Daisuke| Yamane, Mai| Son, Reina| Hasegawa, Kou| Honda, Hiroyuki| Obika, Mikako| Minao, Nozomu| Edahiro, Satoru| Yamada, Norihito| Otsuka, Fumio| |
| 抄録 | Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN. |
| キーワード | anorexia nervosa glucagon hypoglycemic coma insulin-like growth factor-I liver injury |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 631 |
| 終了ページ | 636 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703046 |
| Web of Science KeyUT | Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa 000711568400001 |
| NAID | 120007166676 |
| JaLCDOI | 10.18926/AMO/62775 |
|---|---|
| フルテキストURL | 75_5_625.pdf |
| 著者 | Iwamuro, Masaya| Yamasaki, Yasushi| Tanaka, Takehiro| Asada, Noboru| Matsuoka, Ken-ichi| Hiraoka, Sakiko| Kawahara, Yoshiro| Okada, Hiroyuki| |
| 抄録 | A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases. |
| キーワード | colorectal lymphoma follicular lymphoma diffuse large B-cell lymphoma histologic transformation |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 625 |
| 終了ページ | 629 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703045 |
| Web of Science KeyUT | 000711561300001 |
| NAID | 120007166675 |
| JaLCDOI | 10.18926/AMO/62774 |
|---|---|
| フルテキストURL | 75_5_611.pdf |
| 著者 | Zhou, Yu| Furutani, Michiyo| Athurupana, Rukmali| Nakatsuka, Mikiya| |
| 抄録 | Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their families’ reactions after the disclosure. We also evaluated the subjects’ mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members. |
| キーワード | disclosure family functioning gender nonconformity mental health transgender |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 611 |
| 終了ページ | 623 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703044 |
| Web of Science KeyUT | 000711561600008 |
| NAID | 120007166674 |
| JaLCDOI | 10.18926/AMO/62772 |
|---|---|
| フルテキストURL | 75_5_595.pdf |
| 著者 | Imai, Norio| Endo, Naoto| Suda, Ken| Suzuki, Hayato| |
| 抄録 | Multidisciplinary approaches such as fracture liaison services (FLS) have been introduced in some countries to reduce medical complications and secondary fractures in patients with fragility hip fracture. We aimed to investigate outcomes in patients with fragility hip fracture following the introduction of FLS. Patients > 50 years old who experienced fragility hip fractures between January 1, 2015 and December 31, 2017 were enrolled, and divided into a control group (without FLS; 94 patients) and FLS group (373 patients). We found that the time from injury to surgery decreased significantly from 2.42 to 1.83 days (p = 0.003), the proportion of patients who underwent surgery within 36 h of injury increased significantly (p = 0.014), and the number of cases with complications after admission decreased significantly (p = 0.004) in the FLS group. Patients with a Barthel index ≥ 80 were more common in the FLS than the control group at 6 , 12, and 24 months following injury (p = 0.046 , 0.018, and 0.048, respectively). Multiple logistic regression analysis revealed the factors associated with postoperative complications and death within 12 or 24 months after injury. Our results indicate that FLS contributed to earlier recovery, rehabilitation following surgery and rehabilitation of medical complications following admission; improved patient activity; and decreased secondary hip fractures. |
| キーワード | postoperative complications fracture liaison services hip fractures multidisciplinary approaches |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 595 |
| 終了ページ | 600 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703042 |
| Web of Science KeyUT | 000711561600006 |
| NAID | 120007166672 |
| JaLCDOI | 10.18926/AMO/62768 |
|---|---|
| フルテキストURL | 75_5_557.pdf |
| 著者 | Takeshima Kohara, Hiroko| Ikeda, Mitsunori | Okawa, Masami| |
| 抄録 | This study examined the relationship between skin physiological indices and pressure ulcers in elderly people. The subjects were 55 bedridden elderly Japanese patients with a median age of 85 years. The following parame-ters were measured using non-invasive devices: skin surface temperature, moisture content in the stratum corneum, moisture content in the dermis, transepidermal water loss as an index of skin barrier function, skin erythema and skin elasticity. The sacral and 2 heel areas were observed as sites predisposed to pressure ulcers. Within one month after measuring the skin physiological indices, we confirmed pressure ulcers of National Pressure Ulcer Advisory Panel classification Stage II or worse based on medical records. Among the 55 patients, 4 (7.3%) prospectively developed a total of 5 pressure ulcers within 16 days. Only the skin erythema score was significantly higher with than without pressure ulcers (p < 0.001). We performed a binary logistic regression analysis and confirmed a significant relationship between pressure-ulcer development and the level of erythema (odds ratio = 1.026; 95% confidence interval: 1.011-1.042). Skin erythema increased before the development of pressure ulcers. Taken together, our results show that the high skin erythema score can be a predictive indicator of pressure ulcers. |
| キーワード | elderly people erythema pressure ulcer skin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 557 |
| 終了ページ | 565 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703038 |
| Web of Science KeyUT | 000711561600002 |
| NAID | 120007166668 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| フルテキストURL | 75_5_549.pdf |
| 著者 | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| キーワード | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 549 |
| 終了ページ | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
| フルテキストURL | 2014-3-1.pdf 2014-3-2.pdf 2014-3-3.pdf 2014-3-4.pdf 2014-3-5.pdf 2014-3-6.pdf 2014-3-7.pdf |
|---|---|
| 著者 | 岡山大学教育学部| 岡山大学教師教育開発センター| |
| 発行日 | 2015-03 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| ライセンス | https://creativecommons.org/licenses/by/4.0 |
| フルテキストURL | 2014-4-1.pdf 2014-4-2.pdf 2014-4-3.pdf 2014-4-4.pdf 2014-4-5.pdf |
|---|---|
| 著者 | 岡山大学大学院教育学研究科教職実践専攻（教職大学院）| |
| 寄与者 | 黒﨑 東洋郎| |
| 発行日 | 2015-03 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | 2015-3-1.pdf 2015-3-2.pdf |
|---|---|
| 著者 | 岡山大学教育学部| 岡山大学教師教育開発センター| |
| 発行日 | 2016-03 |
| 開始ページ | 1 |
| 終了ページ | 73 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| ライセンス | https://creativecommons.org/licenses/by/4.0 |
| フルテキストURL | 2015-4-1.pdf 2015-4-2.pdf 2015-4-3.pdf 2015-4-4.pdf |
|---|---|
| 著者 | 岡山大学大学院教育学研究科 教職実践専攻(教職大学院)| |
| 寄与者 | 黒﨑 東洋郎| |
| 発行日 | 2016-03 |
| 言語 | 日本語 |
| 著作権者 | 文部科学省 |
| 論文のバージョン | publisher |
| ライセンス | https://creativecommons.org/licenses/by/4.0 |
| フルテキストURL | fulltext20211007-1.pdf |
|---|---|
| 著者 | Harada, Ko| Hagiya, Hideharu| Funahashi, Tomoko| Koyama, Toshihiro| Kano, Mitsunobu R| Otsuka, Fumio| |
| キーワード | nontuberculous mycobacteria trend analysis |
| 備考 | This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record [Ko Harada, Hideharu Hagiya, Tomoko Funahashi, Toshihiro Koyama, Mitsunobu R Kano, Fumio Otsuka, Trends in the Nontuberculous Mycobacterial Disease Mortality Rate in Japan: A Nationwide Observational Study, 1997–2016, Clinical Infectious Diseases, Volume 73, Issue 2, 15 July 2021, Pages e321–e326, https://doi.org/10.1093/cid/ciaa810] is available online at:[https://doi.org/10.1093/cid/ciaa810].| |
| 発行日 | 2021-6-15 |
| 出版物タイトル | Clinical Infectious Diseases |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Oxford University Press (OUP) |
| 開始ページ | E321 |
| 終了ページ | E326 |
| ISSN | 1058-4838 |
| NCID | AA10822963 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America |
| 論文のバージョン | author |
| PubMed ID | 32556251 |
| DOI | 10.1093/cid/ciaa810 |
| Web of Science KeyUT | 000697378800010 |
| 関連URL | isVersionOf https://doi.org/10.1093/cid/ciaa810 |