検索結果 2861 件
| JaLCDOI | 10.18926/AMO/63748 |
|---|---|
| フルテキストURL | 76_3_355.pdf |
| 著者 | Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi| |
| 抄録 | An 89-year-old male came to the hospital with a complaint of abdominal distension. Abdominal computed tomography showed wall thickening in the descending colon and marked dilatation of the proximal colon, and lower gastrointestinal endoscopy demonstrated a stenosis in the descending colon. Although a biopsy from the stenotic lesion showed calcified eggs of Schistosoma japonicum with no malignant findings, we suspected malignant involvement, so we performed a descending colectomy with regional lymph node dissection. Pathological examination revealed a moderately differentiated adenocarcinoma. The colon cancer was diagnosed as pT4bN0M0, Stage IIc. The patient’s history as a resident of one of the formerly endemic areas of Japan suggests that he may have carried S. japonicum for a long time, and that it may have contributed to carcinogenesis. |
| キーワード | Schistosoma japonicum descending colon cancer carcinogenesis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 355 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790369 |
| Web of Science KeyUT | 000823568300017 |
| JaLCDOI | 10.18926/AMO/63747 |
|---|---|
| フルテキストURL | 76_3_349.pdf |
| 著者 | Ariyasu, Kanazu| Kimura, Shuhei| Matoba, Ryo| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Kanzaki, Yuki| Morizane, Yuki| |
| 抄録 | An 18-year-old male high school student presented to our clinic with bilateral blunt ocular trauma caused by an exercise resistance band (ERB) during a muscle-building exercise. Best-corrected decimal visual acuities (BCVAs) for right and left eyes were light perception and 0.15, respectively. The right eye was operated 10 days after injury for persistent vitreous hemorrhage, and the left eye 5 months later because of macular hole onset. After 36 months, the right eye showed extensive retinal degeneration (BCVA 0.04), and the left eye macular hole closure (BCVA 1.2). ERBs should be used cautiously as they can cause serious ocular trauma. |
| キーワード | exercise resistance band traumatic macular hole traumatic retinal degeneration bilateral blunt ocular trauma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 354 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790368 |
| Web of Science KeyUT | 000823568300016 |
| JaLCDOI | 10.18926/AMO/63746 |
|---|---|
| フルテキストURL | 76_3_343.pdf |
| 著者 | Maki, Yuho| Kiriyama, Yosuke| Ueno, Tsuyoshi| Suehisa, Hiroshi| Shigematsu, Hisayuki| Saeki, Kazuhiko| Harada, Daijiro| Kozuki, Toshiyuki| Teramoto, Norihiro| Yamashita, Motohiro| |
| 抄録 | Localized malignant mesothelioma is a rare disease and little is known about its treatment strategy. We herein report a case of localized malignant pleural mesothelioma that had infiltrated into the anterior mediastinum, which was successfully treated using chemotherapy and conversion surgery. A 63-year-old man with a mediastinal tumor was referred to our hospital. Pathologic analysis of the biopsy specimen showed malignant mesothelioma. Significant tumor shrinkage by cisplatin and pemetrexed was observed and he underwent radical surgery via a median sternotomy. The patient has been disease free for 12 months. |
| キーワード | localized mesothelioma mediastinum cisplatin pemetrexed conversion surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 343 |
| 終了ページ | 347 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790367 |
| Web of Science KeyUT | 000823568300015 |
| JaLCDOI | 10.18926/AMO/63745 |
|---|---|
| フルテキストURL | 76_3_339.pdf |
| 著者 | Yano, Akihiko| Sada, Ken-ei| Sawada, Tsutomu| Ito, Hideki| Yano, Hiroko| Ikeda, Tatsuya| |
| 抄録 | A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patient’s serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases. |
| キーワード | hypocalcaemia thyroidectomy proton pump inhibitors hypomagnesemia rhabdomyolysis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790366 |
| Web of Science KeyUT | 000823568300014 |
| JaLCDOI | 10.18926/AMO/63744 |
|---|---|
| フルテキストURL | 76_3_333.pdf |
| 著者 | Akagawa, Manabu| Miyakoshi, Naohisa| Tsuchie, Hiroyuki| Kasukawa, Yuji| Kawaragi, Takashi| Nagahata, Itsuki| Suzuki, Masazumi| Yoshikawa, Takayuki| Abe, Toshiki| Shimada, Yoichi| |
| 抄録 | We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture. |
| キーワード | atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790365 |
| Web of Science KeyUT | 000823568300013 |
| JaLCDOI | 10.18926/AMO/63743 |
|---|---|
| フルテキストURL | 76_3_329.pdf |
| 著者 | Inomata, Yuki| Hanaoka, Yoshiki| Fujii, Yu| Ogiwara, Toshihiro| Horiuchi, Tetsuyoshi| |
| 抄録 | Putaminal hemorrhage is a common type of spontaneous cerebral hemorrhage. However, to our knowledge, there have been no reports of sequential cerebral hemorrhage and infarction in the same perforating arterial territory. Herein, we present the first reported case of the sequential development of putaminal hemorrhage and corona radiata infarction in the same lenticulostriate arterial (LSA) territory. Early intensive blood pressure lowering treatment may have aggravated ischemic damage. If a patient presents with motor weakness that cannot be explained by putaminal hemorrhage, the sequential development of corona radiata infarction in the same LSA territory should be ruled out. |
| キーワード | arterial dissection cerebral hemorrhage cerebral infarction lenticulostriate artery perforating artery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 329 |
| 終了ページ | 332 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790364 |
| Web of Science KeyUT | 000823568300012 |
| JaLCDOI | 10.18926/AMO/63742 |
|---|---|
| フルテキストURL | 76_3_323.pdf |
| 著者 | Hosomoto, Kakeru| Sasaki, Tatsuya| Kawai, Koji| Okazaki, Yosuke| Hyodo, Yuki| Shibata, Takashi| Sasada, Susumu| Yasuhara, Takao| Kobayashi, Katsuhiro| Yanai, Hiroyuki| Date, Isao| |
| 抄録 | Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case. |
| キーワード | cortical tuber epilepsy focal cortical dysplasia transmantle sign tuberous sclerosis complex |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 328 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790363 |
| Web of Science KeyUT | 000823568300011 |
| JaLCDOI | 10.18926/AMO/63741 |
|---|---|
| フルテキストURL | 76_3_317.pdf |
| 著者 | Yamamoto, Norio| Inoue, Tomoo| Yusuke, Mochizuki| Tomoyuki, Noda| Keisuke, Kawasaki| Toshifumi, Ozaki| |
| 抄録 | Secondary hip fractures (SHFs) rarely occur after intramedullary nailing (IMN) fixation without femoral neck fixation for atypical femoral fractures (AFFs). We report three cases of older Japanese women who sustained SHFs presumably caused by osteoporosis and peri-implant stress concentration around the femoral neck after undergoing IMN without femoral neck fixation for AFF. All cases were fixed with malalignment. In AFF patients, postoperative changes due to postoperative femoral bone malalignment may affect the peri-implant mechanical environment around the femoral neck, which can result in insufficiency fractures. At the first AFF surgery, we recommend femoral neck fixation after adequate reduction is achieved. |
| キーワード | atypical femoral fracture bone malalignment intramedullary nail femoral neck fracture hip fracture |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790362 |
| Web of Science KeyUT | 000823568300010 |
| JaLCDOI | 10.18926/AMO/63740 |
|---|---|
| フルテキストURL | 76_3_307.pdf |
| 著者 | Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki| |
| 抄録 | In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists. |
| キーワード | home visit pharmacist meeting inquiry home health care |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 315 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790361 |
| Web of Science KeyUT | 000823568300001 |
| JaLCDOI | 10.18926/AMO/63739 |
|---|---|
| フルテキストURL | 76_3_297.pdf |
| 著者 | Kuroda, Masahiro| Konishi, Kohei| Sugimoto, Kohei| Yoshimura, Yuuki| Hamada, Kentaro| Khasawnehc, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kamizaki, Ryo| Kurozumi, Akira| Matsushita, Toshi| Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| 抄録 | Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research. |
| キーワード | fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 297 |
| 終了ページ | 305 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790360 |
| Web of Science KeyUT | 000823568300009 |
| JaLCDOI | 10.18926/AMO/63738 |
|---|---|
| フルテキストURL | 76_3_291.pdf |
| 著者 | Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro| |
| 抄録 | Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure. |
| キーワード | total hip arthroplasty bacterial contamination periprosthetic joint infection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 295 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790359 |
| Web of Science KeyUT | 000823568300008 |
| JaLCDOI | 10.18926/AMO/63722 |
|---|---|
| フルテキストURL | 76_3_281.pdf |
| 著者 | Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong| |
| 抄録 | Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions. |
| キーワード | periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 281 |
| 終了ページ | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790358 |
| Web of Science KeyUT | 000823568300007 |
| JaLCDOI | 10.18926/AMO/63721 |
|---|---|
| フルテキストURL | 76_3_273.pdf |
| 著者 | Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro| |
| 抄録 | Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination. |
| キーワード | hip total hip arthroplasty arthroplasty radiography lordosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 273 |
| 終了ページ | 280 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790357 |
| Web of Science KeyUT | 000823568300006 |
| JaLCDOI | 10.18926/AMO/63720 |
|---|---|
| フルテキストURL | 76_3_265.pdf |
| 著者 | Kosaki, Yoshinori| Naito, Hiromichi| Iida, Atsuyoshi| Ihoriya, Hiromi| Nojima, Tsuyoshi| Yamada, Taihei| Yamamoto, Hirotsugu| Nakamura, Shunsuke| Mandai, Yasuhiro| Nakao, Atsunori| |
| 抄録 | Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons. |
| キーワード | BLS medical education emergency medicine resuscitation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 271 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790356 |
| Web of Science KeyUT | 000823568300005 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| フルテキストURL | 76_3_255.pdf |
| 著者 | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| 抄録 | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| キーワード | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
| JaLCDOI | 10.18926/AMO/63718 |
|---|---|
| フルテキストURL | 76_3_247.pdf |
| 著者 | Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu| |
| 抄録 | Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients. |
| キーワード | vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 247 |
| 終了ページ | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790354 |
| Web of Science KeyUT | 000823568300003 |
| JaLCDOI | 10.18926/AMO/63717 |
|---|---|
| フルテキストURL | 76_3_235.pdf |
| 著者 | Tenta, Masafumi| Eguchi, Jun| Wada, Jun| |
| 抄録 | The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity. |
| キーワード | adipose tissue skeletal muscle obesity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 235 |
| 終了ページ | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790353 |
| Web of Science KeyUT | 000823568300002 |
| JaLCDOI | 10.18926/AMO/63428 |
|---|---|
| フルテキストURL | 76_2_229.pdf |
| 著者 | Kono, Takashi| Monden, Nobuya| Chikuie, Nobuyuki| Taruya, Takayuki| Hamamoto, Takao| Ishino, Takashi| Ueda, Tsutomu| Takeno, Sachio| |
| 抄録 | We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy. |
| キーワード | head and neck osteosarcomas tumor suppressor p16 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 229 |
| 終了ページ | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503452 |
| Web of Science KeyUT | 000792291900006 |
| JaLCDOI | 10.18926/AMO/63427 |
|---|---|
| フルテキストURL | 76_2_225.pdf |
| 著者 | Mori, Yu| Sano, Yoshifumi| Sugimoto, Ryujiro| Sakao, Nobuhiko| Ryuko, Tsuyoshi| Takeda, Masashi| Kitazawa, Riko| Yukumi, Shungo| Izutani, Hironori| |
| 抄録 | A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma. |
| キーワード | renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 225 |
| 終了ページ | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503451 |
| Web of Science KeyUT | 000792291900005 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| フルテキストURL | 76_2_217.pdf |
| 著者 | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| 抄録 | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| キーワード | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 217 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |