検索結果 47765 件
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| フルテキストURL | 79_3_167.pdf |
| 著者 | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| 抄録 | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| キーワード | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-06 |
| 巻 | 79巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| フルテキストURL | 79_3_157.pdf |
| 著者 | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| 抄録 | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| キーワード | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-06 |
| 巻 | 79巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 157 |
| 終了ページ | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| フルテキストURL | 79_3_147.pdf |
| 著者 | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| 抄録 | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| キーワード | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-06 |
| 巻 | 79巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Bufetov, Alexander I.| Kawamoto, Yosuke| |
| キーワード | Random matrices Intertwining relation Interacting Brownian motions |
| 備考 | The version of record of this article, first published in Journal of Statistical Physics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10955-025-03441-w| |
| 発行日 | 2025-04-16 |
| 出版物タイトル | Journal of Statistical Physics |
| 巻 | 192巻 |
| 号 | 5号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 58 |
| ISSN | 1572-9613 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| DOI | 10.1007/s10955-025-03441-w |
| Web of Science KeyUT | 001469294100001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s10955-025-03441-w |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kondo, Maiko| Kurita, Yoshihiko| Fukushima, Yosuke| Shigemitsu, Yusuke| Hirai, Kenta| Kawamoto, Yuya| Hara, Mayuko| Kanazawa, Tomoyuki| Iwasaki, Tatsuo| Kotani, Yasuhiro| Kasahara, Shingo| Tsukahara, Hirokazu| Baba, Kenji| |
| キーワード | Ultra-high-pressure balloon Balloon angioplasty Congenital heart disease |
| 備考 | The version of record of this article, first published in Heart and Vessels, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00380-025-02547-1| |
| 発行日 | 2025-05-06 |
| 出版物タイトル | Heart and Vessels |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0910-8327 |
| NCID | AA10452161 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 40328970 |
| DOI | 10.1007/s00380-025-02547-1 |
| Web of Science KeyUT | 001482109000001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00380-025-02547-1 |
| 著者 | Tokushige, Keisuke| Abe, Takumi| |
|---|---|
| キーワード | Deaminokynurenines Enolates Indoline hemiaminals Potassium tertbutoxide Tautomerism |
| 備考 | This is the peer reviewed version of the following article: [K. Tokushige, T. Abe*, Asian Journal of Organic Chemistry. 2025, 00. https://doi.org/10.1002/ajoc.202500439], which has been published in final form at [https://doi.org/10.1002/ajoc.202500439]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
| 発行日 | 2025-05-01 |
| 出版物タイトル | Asian Journal of Organic Chemistry |
| 出版者 | Wiley |
| 開始ページ | e202500439 |
| ISSN | 2193-5807 |
| NCID | AA12586329 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 Wiley-VCH GmbH |
| 論文のバージョン | author |
| DOI | 10.1002/ajoc.202500439 |
| Web of Science KeyUT | 001479453400001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ajoc.202500439 |
| 著者 | Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito| |
|---|---|
| キーワード | adverse event breast cancer pertuzumab trastuzumab VigiBase |
| 備考 | This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025; 1-13. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
| 発行日 | 2025-05-08 |
| 出版物タイトル | British Journal of Clinical Pharmacology |
| 出版者 | Wiley |
| ISSN | 0306-5251 |
| NCID | AA00574388 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 British Pharmacological Society. |
| 論文のバージョン | author |
| PubMed ID | 40344285 |
| DOI | 10.1002/bcp.70094 |
| Web of Science KeyUT | 001483932800001 |
| 関連URL | isVersionOf https://doi.org/10.1002/bcp.70094 |
| 著者 | JINZENJI, Masao| MATSUZAKA, Kohki| |
|---|---|
| キーワード | generalized hypergeometric functions Givental's I-function moduli space of quasimaps |
| 備考 | This fulltext file will be available in Apr. 2028.| |
| 発行日 | 2025-04 |
| 出版物タイトル | Journal of the Mathematical Society of Japan |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Mathematical Society of Japan (Project Euclid) |
| 開始ページ | 449 |
| 終了ページ | 482 |
| ISSN | 0025-5645 |
| NCID | AA0070177X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Mathematical Society of Japan |
| 論文のバージョン | publisher |
| DOI | 10.2969/jmsj/90489048 |
| Web of Science KeyUT | 001473865200001 |
| 関連URL | isVersionOf https://doi.org/10.2969/jmsj/90489048 |
| フルテキストURL | jhg_3_contents_e.pdf |
|---|---|
| 出版物タイトル | 老年人文研究 |
| 発行日 | 2024-03-31 |
| 巻 | 3巻 |
| ISSN | 2435-5747 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | jhg_3_colophon.pdf |
|---|---|
| 出版物タイトル | 老年人文研究 |
| 発行日 | 2024-03-31 |
| 巻 | 3巻 |
| ISSN | 2435-5747 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/JHG/68714 |
|---|---|
| タイトル（別表記） | Forming a mindset of A consideration on being a burden : Relationship with education |
| フルテキストURL | jhg_3_22_54.pdf |
| 著者 | 鄧 小凡| |
| 出版物タイトル | 老年人文研究 |
| 発行日 | 2024-03-31 |
| 巻 | 3巻 |
| 開始ページ | 22 |
| 終了ページ | 54 |
| ISSN | 2435-5747 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/JHG/68713 |
|---|---|
| タイトル（別表記） | Memoirs of NISHIDA Kitaro's Death |
| フルテキストURL | jhg_3_1_21.pdf |
| 著者 | 鈴木 亮三| 山本 紘一郎| 小比賀 美香子| |
| 出版物タイトル | 老年人文研究 |
| 発行日 | 2024-03-31 |
| 巻 | 3巻 |
| 開始ページ | 1 |
| 終了ページ | 21 |
| ISSN | 2435-5747 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | jhg_3_contents.pdf |
|---|---|
| 出版物タイトル | 老年人文研究 |
| 発行日 | 2024-03-31 |
| 巻 | 3巻 |
| ISSN | 2435-5747 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fukushima, Kazuhiko| Tsuji, Kenji| Nakanoh, Hiroyuki| Uchida, Naruhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun| |
| キーワード | artificial intelligence case reports peritoneal dialysis text mining |
| 発行日 | 2025-03-26 |
| 出版物タイトル | Therapeutic Apheresis and Dialysis |
| 巻 | 29巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | 459 |
| 終了ページ | 470 |
| ISSN | 1744-9979 |
| NCID | AA12013945 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 40143459 |
| DOI | 10.1111/1744-9987.70013 |
| Web of Science KeyUT | 001480833800002 |
| 関連URL | isVersionOf https://doi.org/10.1111/1744-9987.70013 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakanoh, Hiroyuki| Tsuji, Kenji| Fukushima, Kazuhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun| |
| キーワード | Acute kidney injury Drug-induced nephrotoxicity Kidney organoid Kidney stem cell |
| 発行日 | 2025-02-20 |
| 出版物タイトル | American Journal of Nephrology |
| 出版者 | S. Karger AG |
| ISSN | 0250-8095 |
| NCID | AA10424676 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39978331 |
| DOI | 10.1159/000544795 |
| Web of Science KeyUT | 001468823100001 |
| 関連URL | isVersionOf https://doi.org/10.1159/000544795 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara| |
| キーワード | animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin |
| 発行日 | 2025-05-01 |
| 出版物タイトル | Infection and Immunity |
| 出版者 | American Society for Microbiology |
| ISSN | 0019-9567 |
| NCID | AA00673732 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 Kuriu et al. |
| 論文のバージョン | publisher |
| PubMed ID | 40310291 |
| DOI | 10.1128/iai.00126-25 |
| Web of Science KeyUT | 001479415700001 |
| 関連URL | isVersionOf https://doi.org/10.1128/iai.00126-25 |
| 著者 | Kawajiri, Takahiro| Hosoya, Masahiro| Goda, Satoshi| Sato, Eisuke| Suga, Seiji| |
|---|---|
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.5c01138.| This fulltext file will be available in Apr. 2026.| |
| 発行日 | 2025-04-29 |
| 出版物タイトル | Organic Letters |
| 巻 | 27巻 |
| 号 | 18号 |
| 出版者 | American Chemical Society (ACS) |
| 開始ページ | 4737 |
| 終了ページ | 4741 |
| ISSN | 1523-7060 |
| NCID | AA11347843 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 American Chemical Society |
| 論文のバージョン | author |
| PubMed ID | 40302371 |
| DOI | 10.1021/acs.orglett.5c01138 |
| Web of Science KeyUT | 001479279200001 |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.orglett.5c01138 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | NAKAMURA, Daisuke| AOYA, Mutsuki| OKAMURA, Tomoki| |
| キーワード | Sambagawa belt Iratsu body Metagabbro Granulite Hanging wall |
| 発行日 | 2025 |
| 出版物タイトル | Journal of Mineralogical and Petrological Sciences |
| 巻 | 120巻 |
| 号 | 1号 |
| 出版者 | Japan Association of Mineralogical Sciences |
| 開始ページ | 241001 |
| ISSN | 1345-6296 |
| NCID | AA11460926 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 Japan Association of Mineralogical Sciences |
| 論文のバージョン | publisher |
| DOI | 10.2465/jmps.241001 |
| Web of Science KeyUT | 001478417000001 |
| 関連URL | isVersionOf https://doi.org/10.2465/jmps.241001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Watanabe, Yuta| Kunishi, Kotomi| Matsui, Hidenori| Sakata, Nanami| Noutoshi, Yoshiteru| Toyoda, Kazuhiro| Ichinose, Yuki| |
| キーワード | horizontal gene transfer integrative and conjugative elements pathogenicity island Pseudomonas syringae tabtoxin |
| 発行日 | 2025-05-12 |
| 出版物タイトル | Molecular Plant Pathology |
| 巻 | 26巻 |
| 号 | 5号 |
| 出版者 | Wiley |
| 開始ページ | e70087 |
| ISSN | 1464-6722 |
| NCID | AA11546828 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 40356278 |
| DOI | 10.1111/mpp.70087 |
| Web of Science KeyUT | 001488297600001 |
| 関連URL | isVersionOf https://doi.org/10.1111/mpp.70087 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kuang, Canyan| Hirai, Anna| Kamei‑Νagata, Chiaki| Nango, Hiroshi| Ohtani, Masahiro| Omori, Kazuhiro| Takashiba, Shogo| |
| キーワード | AGE experimental periodontitis bone resorption inflammation osteoclasts |
| 発行日 | 2025-04-11 |
| 出版物タイトル | Biomedical Reports |
| 巻 | 22巻 |
| 号 | 6号 |
| 出版者 | Spandidos Publications |
| 開始ページ | 97 |
| ISSN | 2049-9434 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright © 2025 Kuang et al. |
| 論文のバージョン | publisher |
| PubMed ID | 40297801 |
| DOI | 10.3892/br.2025.1975 |
| Web of Science KeyUT | 001477956200001 |
| 関連URL | isVersionOf https://doi.org/10.3892/br.2025.1975 |