| JaLCDOI |
10.18926/AMO/48264
|
| フルテキストURL |
66_2_143.pdf.pdf
|
| 著者 |
Watanabe, Makiko|
Ueno, Hiroshi|
Suemitsu, Shunsuke|
Yokobayashi, Eriko|
Matsumoto, Yosuke|
Usui, Shinichi|
Sujiura, Hiroko|
Okamoto, Motoi|
|
| 抄録 |
Recent studies have demonstrated the important role of immune molecules in the development of neuronal
circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin-
containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance
of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons
in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
|
| キーワード |
parvalbumin
fast-spiking interneurons
FcγRllB
barrel cortex
sensory deprivation
|
| Amo Type |
Original Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 |
2012-04
|
| 巻 |
66巻
|
| 号 |
2号
|
| 出版者 |
Okayama University Medical School
|
| 開始ページ |
143
|
| 終了ページ |
154
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 著作権者 |
CopyrightⒸ 2012 by Okayama University Medical School
|
| 論文のバージョン |
publisher
|
| 査読 |
有り
|
| PubMed ID |
22525472
|
| Web of Science KeyUT |
000303175300007
|
