このエントリーをはてなブックマークに追加
ID 47680
フルテキストURL
著者
Singaravel, Muniyandi Department of Physics, Biology and Informatics, Faculty of Science, Research Institute of Time Studies, Yamaguchi University
Fujisawa, Yuko Suntory Institute for Bioorganic Research
Hisada, Miki Suntory Institute for Bioorganic Research
Saifullah, ASM Department of Physics, Biology and Informatics, Faculty of Science, Research Institute of Time Studies, Yamaguchi University
Tomioka, Kenji Department of Physics, Biology and Informatics, Faculty of Science, Research Institute of Time Studies, Yamaguchi University
抄録
Pigment-dispersing factors (PDFs) are octadeca-peptides widely distributed in insect optic lobes and brain. In this study, we have purified PDF and determined its amino acid sequence in the cricket Gryllus bimaculatus. Its primary structure was NSEIINSLLGLPKVLNDA-NH2, homologous to other PDH family members so far reported. When injected into the optic lobe of experimentally blinded adult male crickets, Gryllus-PDF induced phase shifts in their activity rhythms in a phase dependent and dose dependent manner. The resulted phase response curve (PRC) showed delays during the late subjective night to early subjective day and advances during the mid subjective day to mid subjective night. The PRC was different in shape from those for light, serotonin and temperature. These results suggest that PDF plays a role in phase regulation of the circadian clock through a separate pathway from those of other known phase regulating agents.
キーワード
pigment-dispersing factor
circadian rhythm
crickets
phase shifts
phase response curve
発行日
2003-11
出版物タイトル
Zoological Science
20巻
11号
出版者
Zoological Society of Japan
出版者(別表記)
日本動物学会
開始ページ
1347
終了ページ
1354
ISSN
0289-0003
NCID
AA10545874
資料タイプ
学術雑誌論文
言語
English
著作権者
© 2003 Zoological Society of Japan
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT