ID | 61326 |
フルテキストURL | |
著者 |
Shikata, Kenichi
Center for Innovative Clinical Medicine, Okayama University Hospital
ORCID
Kaken ID
publons
researchmap
Utsunomiya, Kazunori
The Japan Diabetes Society
Koya, Daisuke
The Japan Diabetes Society
Nishimura, Rimei
The Japan Diabetes Society
Miyamoto, Satoshi
Center for Innovative Clinical Medicine, Okayama University Hospital
Kaken ID
Tajima, Naoko
The Japan Diabetes Society
the JDCP study group
|
抄録 | Aims/Introduction
To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study.
Materials and Methods
We used the data of 355 patients with type 1 diabetes and 5,194 patients with type 2 diabetes to evaluate the prevalence of albuminuria and renal dysfunction, and related factors. A binomial logistic regression analysis was used to investigate independent contributing factors for estimated glomerular filtration rate <60 mL/min/1.73 m2 or albuminuria.
Results
The prevalence of microalbuminuria and macroalbuminuria was 15.2% (54/355) and 3.1% (11/355) in type 1 diabetes patients, and 25.0% (1,298/5,194) and 5.1% (265/5,194) in type 2 diabetes patients, respectively. The proportion of renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) was 9.9% (35/355) in type 1 diabetes patients, and 15.3% (797/5,194) in type 2 diabetes patients. The proportion of patients with renal dysfunction with normoalbuminuria was 7.3% (26/355) for type 1 diabetes patients, and 9.0% (467/5,194) for type 2 diabetes patients. The factors related to albuminuria in type 2 diabetes patients were glycated hemoglobin, hypertension, age, duration of diabetes, body mass index and estimated glomerular filtration rate. In contrast, factors to related renal dysfunction were age, duration of diabetes, dyslipidemia, hypertension, body mass index, male sex and albuminuria.
Conclusions
We showed the recent prevalence of albuminuria and renal dysfunction, and related factors in Japanese type 1 and type 2 diabetes patients using the baseline data of the Japan Diabetes Complication and its Prevention prospective study. The current results suggest that renal disease in patients with type 2 diabetes is heterogeneous, and different mechanisms might be involved in albuminuria and deterioration of renal function.
|
キーワード | Diabetic nephropathy
Diabetic kidney disease
Japan Diabetes Complication and its Prevention study
|
発行日 | 2020-05-17
|
出版物タイトル |
Journal of Diabetes Investigation
|
巻 | 11巻
|
号 | 2号
|
出版者 | Wiley
|
開始ページ | 325
|
終了ページ | 332
|
ISSN | 2040-1116
|
NCID | AA12488319
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2019 The Authors.
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1111/jdi.13116
|
ライセンス | https://creativecommons.org/licenses/by-nc/4.0/
|