ID | 54741 |
フルテキストURL | |
著者 |
Furuya, K.
Allergy Center and Institute for Clinical Research, Mie National Hospital
Nagao, M.
Allergy Center and Institute for Clinical Research, Mie National Hospital
Sato, Y.
Department of Global Clinical Research, Graduate School of Medicine, Chiba University
Ito, S.
Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
Fujisawa, T.
Allergy Center and Institute for Clinical Research, Mie National Hospital
IPAD3g investigators
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抄録 | Background: Specific IgE (sIgE) is often used to predict oral food challenge (OFC) outcomes in food allergy, but interpretation of the results may vary depending on the assay method employed and the patient population tested. The aim of this study was to use two commercial assay systems to determine egg-sIgE values predictive of allergy within the most common populations treated at pediatric clinics.
Methods: In a multicenter prospective study, 433 children with suspected or confirmed egg allergy underwent oral challenge (OFC) using cooked egg (CE) and raw egg (RE) powders to diagnose either true allergy in 1-year-old (group A, n = 220) or tolerance in 2- to 6-year-old (group B, n = 213). Egg white (EW)- and ovomucoid (OM)-sIgE values were measured using the ImmunoCAP(®) sIgE (ImmunoCAP) and the IMMULITE(®) 2000 3 gAllergy(™) (3gAllergy) systems. Children were recruited from six primary care clinics and 18 hospitals in Japan. Results: Receiver-operating characteristic (ROC) curve analysis yielded similar areas under the curve (AUC) for the two assays (0.7-0.8). The optimal cutoff values and the probability curves (PCs) of the sIgE by the two assays to predict CE and RE OFC outcomes were determined for both groups. Values for 3gAllergy were higher than for ImmunoCAP; however, correlation of sIgE and predicted probability calculated by PCs were strong between the two methods. Conclusions: Cutoff values and PCs for egg-sIgE established using both ImmunoCAP and 3gAllergy may be useful for predicting egg allergy in early childhood patient populations. |
キーワード | egg allergy
oral food challenge
predictive value
probability curve
specific IgE
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備考 | Masanori Ikeda as IPAD3g investigators
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発行日 | 2016-04
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出版物タイトル |
Allergy
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巻 | 71巻
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号 | 10号
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出版者 | Wiley
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開始ページ | 1435
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終了ページ | 1443
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ISSN | 0105-4538
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NCID | AA00518456
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1111/all.12912
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Citation | Furuya K, Nagao M, Sato Y, Ito S, Fujisawa T; IPAD3g investigators. Predictive values of egg-specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study. Allergy. 2016;71(10):1435‐1443. doi:10.1111/all.12912
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