ID | 56686 |
フルテキストURL | |
著者 |
Abdel‐Sattar, El‐Shaymaa
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Miyoshi, Shin‐ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Elgaml, Abdelaziz
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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抄録 | Vibrio mimicus is an estuarine bacterium, while it can cause severe diarrhea, wound infection, and otitis media in humans. This pathogen secretes a relatively important toxin named V. mimicus metalloprotease (VMP). In this study, we clarified regulation of the VMP production according to the quorum-sensing master regulatory protein named LuxR. First, the full length of luxR gene, encoding LuxR, was detected in V. mimicus strain E-37, an environmental isolate. Next, the putative consensus binding sequence of LuxR protein could be detected in the upstream (promoter) region of VMP encoding gene, vmp. Finally, the effect of disruption of luxR gene on the expression of vmp and production of VMP was evaluated. Namely, the expression of vmp was significantly diminished by luxR disruption and the production of VMP was severely altered. Taken together, here we report that VMP production is under the positive regulation of the quorum-sensing master regulatory protein, LuxR.
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キーワード | LuxR protein
Metalloprotease
Quorum-sensing
Vibrio mimicus
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備考 | This is an Accepted Manuscript of an article published by WILEY-BLACKWELL
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発行日 | 2016-05-10
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出版物タイトル |
Journal of Basic Microbiology
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巻 | 56巻
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号 | 10号
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出版者 | WILEY-BLACKWELL
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開始ページ | 1051
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終了ページ | 1058
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ISSN | 0233111X
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NCID | AA10522008
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1002/jobm.201600002
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プロジェクト |
インド感染症共同研究
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