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ID 48172
フルテキストURL
著者
Kitamatsu, Mizuki Department of Medical and Bioengineering, Graduate School of Natural Science and Technology, Okayama University
Sisido, Masahiko
抄録
We describe the fluorescence quenching-based quantification of complementary parallel and antiparallel hybrids of DNAs with pyrrolidine-based oxypeptide nucleic acids (POPNAs). When BODIPY-modified DNAs as fluorescent probe formed hybrids with complementary POPNAs, fluorescence of the BODIPY was effectively quenched by the guanine unit and the Lys unit on the POPNAs. The orientations of hybrids of POPNA with DNA were estimated by the quenching efficiencies of two BODIPY-modified DNAs . As a result, we clarified that configurations of POPNAs affect the extent of orientation of the hybrid duplexes.
発行日
2011-04-28
出版物タイトル
MedChemComm
2巻
7号
出版者
The Royal Society of Chemistry
開始ページ
607
終了ページ
610
ISSN
2040-2503
NCID
AA12488374
資料タイプ
学術雑誌論文
言語
English
著作権者
© The Royal Society of Chemistry
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT