ID | 61260 |
フルテキストURL | |
著者 |
Chen, Xinyu
Department of Nuclear Medicine, University Hospital of Würzburg
Kudo, Takashi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Lapa, Constantin
Department of Nuclear Medicine, University Hospital of Würzburg
Buck, Andreas
Department of Nuclear Medicine, University Hospital of Würzburg
Higuchi, Takahiro
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
|
抄録 | The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also used in the therapeutic applications against certain types of neuroendocrine tumors, as exemplified by the clinically used 123/131I-MIBG as theranostic single-photon emission computed tomography (SPECT) agent. With the development of more advanced positron emission tomography (PET) technology, more radiotracers targeting NET have been reported, with superior temporal and spatial resolutions, along with the possibility of functional and kinetic analysis. More recently, fluorine-18-labelled NET tracers have drawn increasing attentions from researchers, due to their longer radiological half-life relative to carbon-11 (110 min vs. 20 min), reduced dependence on on-site cyclotrons, and flexibility in the design of novel tracer structures. In the heart, certain NET tracers provide integral diagnostic information on sympathetic innervation and the nerve status. In the central nervous system, such radiotracers can reveal NET distribution and density in pathological conditions. Most radiotracers targeting cardiac NET-function for the cardiac application consistent of derivatives of either norepinephrine or MIBG with its benzylguanidine core structure, e.g. 11C-HED and 18F-LMI1195. In contrast, all NET tracers used in central nervous system applications are derived from clinically used antidepressants. Lastly, possible applications of NET as selective tracers over organic cation transporters (OCTs) in the kidneys and other organs controlled by sympathetic nervous system will also be discussed.
|
キーワード | Norepinephrine transporter
Benzylguanidine
Phenethylguanidine
Antidepressant
Organic cation transporter
|
発行日 | 2020-04-09
|
出版物タイトル |
Journal of Neural Transmission
|
巻 | 127巻
|
号 | 6号
|
出版者 | Springer
|
開始ページ | 851
|
終了ページ | 873
|
ISSN | 0300-9564
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | Author(s)
|
論文のバージョン | author
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1007/s00702-020-02180-4
|
ライセンス | http://creativecommons.org/licenses/by/4.0/
|