ID | 48556 |
フルテキストURL | |
著者 |
Yoshimoto, Masaaki
Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Toyota, Teruaki
Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
publons
researchmap
|
抄録 | We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
|
キーワード | cold injury
brain edema
0.5 Gy irradiation
antioxidative function
|
発行日 | 2012-02-01
|
出版物タイトル |
Inflammation
|
巻 | 35巻
|
号 | 1号
|
出版者 | Springer Science+Business Media, LLC
|
開始ページ | 89
|
終了ページ | 97
|
ISSN | 0360-3997
|
資料タイプ |
学術雑誌論文
|
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/48543
|
言語 |
英語
|
著作権者 | © Springer Science+Business Media, LLC 2011
|
論文のバージョン | author
|
査読 |
不明
|
DOI | |
PubMed ID | |
Web of Science KeyUT |