著者 Takami, Tsuneaki| Ohnishi, Norikazu| Kurita, Yuko| Iwamura, Shoko| Ohnishi, Miwa| Kusaba, Makoto| Mimura, Tetsuro| Sakamoto, Wataru|
抄録 Mitochondria and chloroplasts (plastids) both harbour extranuclear DNA that originates from the ancestral endosymbiotic bacteria. These organelle DNAs (orgDNAs) encode limited genetic information but are highly abundant, with multiple copies in vegetative tissues, such as mature leaves. Abundant orgDNA constitutes a substantial pool of organic phosphate along with RNA in chloroplasts, which could potentially contribute to phosphate recycling when it is degraded and relocated. However, whether orgDNA is degraded nucleolytically in leaves remains unclear. In this study, we revealed the prevailing mechanism in which organelle exonuclease DPD1 degrades abundant orgDNA during leaf senescence. The DPD1 degradation system is conserved in seed plants and, more remarkably, we found that it was correlated with the efficient use of phosphate when plants were exposed to nutrient-deficient conditions. The loss of DPD1 compromised both the relocation of phosphorus to upper tissues and the response to phosphate starvation, resulting in reduced plant fitness. Our findings highlighted that DNA is also an internal phosphate-rich reservoir retained in organelles since their endosymbiotic origin.
備考 This is an Accepted Manuscript of an article published by Springer Nature Publishing AG This fulltext will be available in May 2019
発行日 2018-05-12
出版物タイトル Nature Plants
4巻
出版者 Springer Nature Publishing AG
開始ページ 1044
終了ページ 1055
ISSN 20550278
NCID AA1273934X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30420711
DOI 10.1038/s41477-018-0291-x
関連URL isVersionOf https://doi.org/10.1038/s41477-018-0291-x