ID | 65917 |
フルテキストURL | |
著者 |
Kawai, Hotaka
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kunisada, Toshiyuki
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
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Inoue, Hirofumi
Department of Pathology, Okayama University Hospital
Futagawa, Mashu
Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Katayama, Haruyoshi
Department of Orthopedic Surgery, Okayama University Hospital
Itano, Takuto
Department of Orthopedic Surgery, Okayama University Hospital
Ozaki, Toshifumi
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
publons
researchmap
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抄録 | Giant cell tumor of bone (GCTB) is an intermediate bone tumor that rarely undergoes malignant transformation. Secondary malignant GCTB (SMGCTB) is defined as a lesion in which high‑grade sarcoma occurs at the site of previously treated GCTB. The present study retrospectively reviewed the medical records of patients with GCTB treated at Okayama University Hospital between April 1986 and April 2020. The clinicopathological and histological features of patients with SMGCTB without prior radiotherapy were investigated. A total of three patients (4%) with SMGCTB were detected, and the tumor sites were the distal ulna, distal femur and sacrum. Two of the patients had been treated with curettage and bone graft, and one had been treated with denosumab. In all cases, the lesions were made up of two components, the conventional GCTB component and the malignant component. The Ki67 labeling index was higher in the malignant components of SMGCTB and metastatic lesions compared with that in primary and recurrent conventional GCTB, or the conventional GCTB component of SMGCTB. Moreover, p53 expression was higher in these same components in patients who underwent curettage and bone grafting; however, there was no difference in the patient that received denosumab treatment. In this patient, clinical cancer genomic profiling revealed loss of CDKN2A, CDKN2B and MTAP expression. All three patients developed distant metastasis. The patients with SMGCTB in the ulna and femur died 13 and 54 months after detection of malignant transformation, respectively. The patient with SMGCTB in the sacrum received carbon‑ion radiotherapy to the sacrum and pazopanib; the treatment was effective and the patient was alive at the last follow‑up 3 years later. In conclusion, p53 may be associated with malignant transformation in GCTB. Future studies should investigate the association of between denosumab treatment and malignant transformation, as well as molecular targeted therapy to improve the clinical outcomes of SMGCTB.
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キーワード | giant cell tumor of bone
malignant transformation
p53
denosumab
molecular targeted therapy
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発行日 | 2022-07-19
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出版物タイトル |
Oncology Letters
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巻 | 24巻
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号 | 3号
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出版者 | Spandidos Publications
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開始ページ | 319
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ISSN | 1792-1074
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © Nakata et al.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3892/ol.2022.13439
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Nakata E, Kawai H, Fujiwara T, Kunisada T, Inoue H, Futagawa M, Katayama H, Itano T and Ozaki T: Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy. Oncol Lett 24: 319, 2022
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