ID | 56203 |
フルテキストURL | |
著者 |
Takamura, Hiroyoshi
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
ORCID
Kaken ID
publons
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Ohashi, Takumi
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kikuchi, Takahiro
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Endo, Noriyuki
Himeji EcoTech Co., Ltd.
Fukuda, Yuji
Himeji EcoTech Co., Ltd.
Kadota, Isao
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
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抄録 | Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 0.30-1.31 μg mL-1. These results show that hybridization of the geraniol and butenolide structural motifs resulted in the enhancement of the antifouling activity.
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備考 | This is an Accepted Manuscript of an article published by Royal Society of Chemistry
We are grateful to Okayama Foundation for Science and Technology and The Yakumo Foundation for Environmental Science for financial support.
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発行日 | 2017-06-13
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出版物タイトル |
Organic and Biomolecular Chemistry
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巻 | 15巻
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号 | 26号
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出版者 | Royal Society of Chemistry
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開始ページ | 5549
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終了ページ | 5555
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ISSN | 14770520
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NCID | AA1168650X
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1039/c7ob01160a
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