ID | 66679 |
フルテキストURL | |
著者 |
Sato, Haruna
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Kato, Kosuke
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Koreishi, Mayuko
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Nakamura, Yoshimasa
Graduate School of Environmental and Life Science, Okayama University
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Tsujino, Yoshio
Graduate School of Science, Technology, and Innovation, Kobe University
Satoh, Ayano
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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抄録 | In atopic dermatitis (AD), nerves are abnormally stretched near the surface of the skin, making it sensitive to itching. Expression of neurotrophic factor Artemin (ARTN) involved in such nerve stretching is induced by the xenobiotic response (XRE) to air pollutants and UV radiation products. Therefore, AD can be monitored by the XRE response. Previously, we established a human keratinocyte cell line stably expressing a NanoLuc reporter gene downstream of XRE. We found that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan metabolite and known inducer of the XRE, increased reporter and Artemin mRNA expression, indicating that FICZ-treated cells could be a model for AD. Lavender essential oil has been used in folk medicine to treat AD, but the scientific basis for its use is unclear. In the present study, we investigated the efficacy of lavender essential oil and its major components, linalyl acetate and linalool, to suppress AD and sensitize skin using the established AD model cell line, and keratinocyte and dendritic cell activation assays. Our results indicated that lavender essential oil from L. angustifolia and linalyl acetate exerted a strong AD inhibitory effect and almost no skin sensitization. Our model is useful in that it can circumvent the practice of using animal studies to evaluate AD medicines.
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発行日 | 2024-01-05
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出版物タイトル |
PLoS ONE
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巻 | 19巻
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号 | 1号
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出版者 | Public Library of Science
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開始ページ | e0296408
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ISSN | 1932-6203
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2024 Sato et al.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0296408
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Sato H, Kato K, Koreishi M, Nakamura Y, Tsujino Y, Satoh A (2024) Aromatic oil from lavender as an atopic dermatitis suppressant. PLoS ONE 19(1): e0296408. https://doi.org/10.1371/journal.pone.0296408
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science
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助成番号 | 18K06133
22K06128
17H03818
20H02933
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