ID | 61554 |
フルテキストURL | |
著者 |
Kojina, Moeko
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Suzuki, Keiichiro
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Nishiwaki, Akane
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Aiba, Tetsuya
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
researchmap
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抄録 | The effects of inflammation on hypoglycemic agents were evaluated in male rats with acute peripheral inflammation (API). Nateglinide (NTG) was utilized as a model compound, since it is a hepatically-metabolized compound and its metabolism is mainly mediated by CYP 2C11 enzyme. In the experiments, rats were subjected to carrageenan injection into their hind paws for API induction, and the plasma concentration profiles of NTG were then examined. In addition, pooled liver microsomes were prepared from control and API rats, and the hepatic drug-metabolizing activity toward NTG and the hepatic expression of CYP2C11 protein were evaluated. It was shown that the plasma concentration of NTG following its intravenous administration decreases at a slower rate in API rats than that in control rats. It was also indicated in the incubation study with the liver microsomes that the hepatic drug-metabolizing activity toward NTG decreases in API rats. Additionally, it was revealed in Western immunoblotting that the hepatic expression of CYP2C11 protein decreases in API rats. These findings suggest that inflammation occurring in peripheral tissues brings about a decrease in hepatic NTG metabolism by suppressing the hepatic expression of CYP2C11 protein, causing an alteration of the plasma concentration profile of NTG with its impaired elimination.
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キーワード | acute inflammation
CYP2C11
hepatic drug metabolism, nateglinide
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発行日 | 2021-01-01
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出版物タイトル |
Biological and Pharmaceutical Bulletin
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巻 | 44巻
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号 | 1号
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出版者 | Pharmaceutical Society of Japan
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開始ページ | 96
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終了ページ | 102
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ISSN | 0918-6158
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NCID | AA10885497
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2021 The Pharmaceutical Society of Japan
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1248/bpb.b20-00677
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助成機関名 |
日本学術振興会
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助成番号 | 15K08097
19K07220
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