ID | 44365 |
フルテキストURL | |
著者 |
Hanaya, Tadashi
Department of Chemistry, Faculty of Science, Okayama University
Kaken ID
publons
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Baba, Hiroki
Department of Chemistry, Faculty of Science, Okayama University
Toyota, Hiroki
Department of Chemistry, Faculty of Science, Okayama University
Yamamoto, Hiroshi
School of Pharmacy, Shujitsu University
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抄録 | L-Rhamnose was led, in a 14-step-sequence, to N2-(N,N-dimethylaminomethylene)-1′-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (23), an appropriately protected precursor for 2′-O-glycosylation, while 4,6-di-O-acetyl-2,3-di-O-(4-methoxybenzyl)-α-d-glucopyranosyl bromide (32), a novel glycosyl donor, was efficiently prepared from d-glucose in 8 steps. The first synthesis of 2′-O-(α-d-glucopyranosyl)biopterin (2a) was achieved by treatment of the key intermediate 23 with 32 in the presence of silver triflate and tetramethylurea, followed by successive removal of the protecting groups.
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キーワード | Pterin glycoside
Pteridine
Glycosylation
Protecting group
Total synthesis
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発行日 | 2009-09-19
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出版物タイトル |
Tetrahedron
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巻 | 65巻
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号 | 38号
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出版者 | Pergamon-Elsevier Science Ltd.
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開始ページ | 7989
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終了ページ | 7997
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ISSN | 0040-4020
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NCID | AA00861787
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.1016/j.tet.2009.07.043
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言語 |
英語
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著作権者 | Copyright © 2009 Elsevier Ltd All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |