ID | 65291 |
フルテキストURL | |
著者 |
Naoe, Shota
Graduate School of Health Sciences, Okayama University
Fujimoto, Yuki
Graduate School of Health Sciences, Okayama University
Murakami, Kaito
Graduate School of Health Sciences, Okayama University
Yukimine, Ryohei
Graduate School of Health Sciences, Okayama University
Tanaka, Ayumi
Graduate School of Health Sciences, Okayama University
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抄録 | The liver's susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate gamma-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors-liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.
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キーワード | low-dose/high-dose-rate irradiation
forced swim test
alcohol
oxidative stress
antioxidants
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発行日 | 2023-05-17
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出版物タイトル |
Journal of Radiation Research
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巻 | 64巻
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号 | 4号
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出版者 | Oxford University Press
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開始ページ | 635
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終了ページ | 643
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ISSN | 0449-3060
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2023.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1093/jrr/rrad030
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Shota Naoe, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka, Takahiro Kataoka, Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice, Journal of Radiation Research, Volume 64, Issue 4, July 2023, Pages 635–643, https://doi.org/10.1093/jrr/rrad030
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助成機関名 |
Japan Society for the Promotion of Science
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助成番号 | JP21K04943
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