Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer

Nakamura, Keiichiro; Matsuoka, Hirofumi; Yorimitsu, Masae; Ogawa, Mariko; Kanemori, Miho; Sueoka, Kotaro; Kozai, Ayumi; Nakamura, Hiroko; Haruma, Tomoko; Shiroyama, Yuko; Hayata, Yuu; Sugii, Hirokazu; Ueda, Akiko; Kurihara, Shuichi; Urayama, Saiko; Shimizu, Miyuki; Masuyama, Hisashi

doi:10.1093/jjco/hyad125

Permalink : http://escholarship.lib.okayama-u.ac.jp/66954

ID	66954
フルテキストURL	fulltext.pdf 428 KB
著者	Nakamura, Keiichiro Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap Matsuoka, Hirofumi Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Yorimitsu, Masae Department of Obstetrics and Gynecology, City Hiroshima Citizens Hospital Ogawa, Mariko Department of Obstetrics and Gynecology, National Organization Fukuyama Medical Center Kanemori, Miho Department of Obstetrics and Gynecology, Fukuyama City Hospital Sueoka, Kotaro Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine Kozai, Ayumi Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine Nakamura, Hiroko Department of Obstetrics and Gynecology, National Hospital Organization KURE Medical Center and Chugoku Cancer Center Haruma, Tomoko Department of Obstetrics and Gynecology, Saiseikai General Hospital Shiroyama, Yuko Department of Obstetrics and Gynecology, Prefectural Hospital Hayata, Yuu Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital Sugii, Hirokazu Department of Obstetrics and Gynecology, National Hospital Organization Iwakuni Clinical Center Ueda, Akiko Department of Obstetrics and Gynecology, Onomichi General Hospital Kurihara, Shuichi Department of Obstetrics and Gynecology, Japanese Red Cross Matsuyama Hospital Urayama, Saiko Department of Obstetrics and Gynecology, Higashi Hiroshima Medical Center Shimizu, Miyuki Department of Obstetrics and Gynecology, Kagawa Rosai Hospital Masuyama, Hisashi Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録	Objective: To investigate whether maintenance treatment could be safely and effectively performed with olaparib, olaparib plus bevacizumab and niraparib in platinum-sensitive advanced ovarian cancer at multiple institutions in Japan. Methods: We investigated progression-free survival and adverse events in 117 patients with platinum-sensitive advanced ovarian cancer treated with maintenance therapy. Results: The median progression-free survival of 117 patients was 20.1 months. Patients with germline BRCA pathogenic variants had a significantly better prognosis than the other groups (P < 0.001). Furthermore, in the multivariate analysis, stage IV (P = 0.016) and germline BRCA wild-type (P ≤ 0.001) were significantly associated with worse progression-free survival in patients with advanced ovarian cancer. Regarding adverse events, all three types of maintenance treatment were significantly worse than chemotherapy given before maintenance treatment with respect to renal function (olaparib, P = 0.037; olaparib plus bevacizumab, P < 0.001; and niraparib, P = 0.016). Conclusion: Maintenance treatment was performed effectively and safely. Renal function deterioration is likely to occur during maintenance treatment, and careful administration is important in platinum-sensitive advanced ovarian cancer.
キーワード	olaparib olaparib plus bevacizumab niraparib renal function
発行日	2023-09-14
出版物タイトル	Japanese Journal of Clinical Oncology
巻	54巻
号	1号
出版者	Oxford University Press (OUP)
開始ページ	31
終了ページ	37
ISSN	1465-3621
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37721176
DOI	10.1093/jjco/hyad125
Web of Science KeyUT	001068527100001
関連URL	isVersionOf https://doi.org/10.1093/jjco/hyad125
ライセンス	https://creativecommons.org/licenses/by/4.0/
Citation	Keiichiro Nakamura, Hirofumi Matsuoka, Masae Yorimitsu, Mariko Ogawa, Miho Kanemori, Kotaro Sueoka, Ayumi Kozai, Hiroko Nakamura, Tomoko Haruma, Yuko Shiroyama, Yuu Hayata, Hirokazu Sugii, Akiko Ueda, Shuichi Kurihara, Saiko Urayama, Miyuki Shimizu, Hisashi Masuyama, Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer, Japanese Journal of Clinical Oncology, Volume 54, Issue 1, January 2024, Pages 31–37, https://doi.org/10.1093/jjco/hyad125
助成機関名	Society of Obstetrics and Gynecology in the Chugoku and Shikoku areas