ID | 30786 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ishikawa, Satoshi
Okayama University
Tanaka, Hiroyuki
Okayama University
Mizushima, Mutsue
Gifu Prefectual Tajimi Hospital
Hashizume, Hiroyuki
Okayama University
Ishida, Yutaka
Okayama University
Inoue, Hajime
Okayama University
|
抄録 | A study was conducted to examine the relationship of testicular atrophy to bone metabolism in male leprosy patients. The study consisted of 31 leprosy patients (mean age: 62.0 years) and 31 healthy control men (mean age: 60.0 years). Measurements were made of their serum levels of free testosterone (FT), estradiol (E2), luteinizing hormone (LH) and 25-hydroxyvitamin D (25 OHD). Bone mineral density (BMD) was measured at radial sites and the lumbar vertebral bodies (L2-L4) by dual-energy X-ray absorptiometry using a Hologic QDR-2000 densitometer. FT and E2 levels were significantly lower and LH levels higher in leprosy patients than in controls. This represents a primary hypogonadal pattern. A value of 7.20pg/ml of FT (= Mean -1 SD of control) was used as a cut off value, and the subjects were subdivided into a hypogonadal group (HG) and a non hypogonadal group (non-HG). When the subjects were compared for differences in age, age at onset of disease, duration of disease, body mass index and BMD, only the duration of disease and BMD were significantly different between the two groups. Furthermore, BMD of the forearm significantly correlated with FT levels (r = 0.689, P < 0.0001). Low BMD may be due to orchitis and testicular atrophy. |
キーワード | osteoporosis
testicular atrophy
testosterone
leprosy
male
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1997-10
|
巻 | 51巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 279
|
終了ページ | 283
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
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言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |