ID | 30766 |
JaLCDOI | |
フルテキストURL | |
著者 |
Iwagaki, Hiromi
Okayama University
Hizuta, Akio
Okayama University
Uomoto, Masashi
Okayama University
Takeuchi, Yoshiaki
Okayama University
Tanaka, Noriaki
Okayama University
|
抄録 | Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia. |
キーワード | cancer cachexia
neuro-endocrine-immune interactio
serotonin
neopterin
cortisol
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1997-08
|
巻 | 51巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 233
|
終了ページ | 236
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |