ID | 31288 |
JaLCDOI | |
フルテキストURL | |
著者 |
Imanaka, Masaaki
Okayama University
Watanabe, Sadahiro
Okayama University
Otsuka, Nagayasu
Okayama University
Nakamoto, Shu
Okayama University
Mori, Masaharu
Okayama University
|
抄録 | The effect of cytochalasin B (CB) on the surface structure of Ehrlich ascites tumor cells was investigated using the scanning electron microscope. The effect occurs in two steps: formation of zeiotic knobs on the cell surface and subsequent grouping of the knobs at one pole of the cell. The early step of zeiotic knob formation occurs at low concentrations of CB (0.5-1 microgram/ml) at 37 degrees C and at high concentrations of the drug (5-10 microgram/ml) at low temperature but within 1 min at 37 degrees C. This step is only partially inhibited by 5 x 10(-3) M sodium azide. The subsequent grouping of zeiotic knobs lasts for more than 2 min at 37 degrees C and occurs only in the case of high concentrations of CB. It is inhibited by sodium azide and is often associated with grouping of the microvilli, which are then lost from all of the cell surface except the area of knob-grouping. |
キーワード | cytochalasin B
Ehrlich ascites tumor cells
zeiosis
scanning electron microscopy.
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1981-06
|
巻 | 35巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 197
|
終了ページ | 204
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |