ID | 30841 |
JaLCDOI | |
フルテキストURL | |
著者 |
Takata, Shinji
Okayama University
|
抄録 | Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture technique of lumphocyte blast transformation. The positive rate with this technique was 10%, and no more than 15% even with the addition of one query positive. One reason for the low positive rate was that there was not only an allergic mechanism at work in the study group but that liver injury due to direct cytotoxicity of the drug was involved also. For a drug such as chlorpromazine with strong cytotoxicity for lymphocytes, it was difficult to demonstrate a relationship between allergic mechanisms and the drug with this method. |
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1977-06
|
巻 | 31巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 187
|
終了ページ | 202
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
NAID |