ID | 32579 |
JaLCDOI | |
フルテキストURL | |
著者 |
Shigehisa, Morio
Okayama University
|
抄録 | For the purpose to see how the suppression of the nucleic acid synthesis disturbs the cell specialization process the author observed the erythroid cell specialization in anemic rats by treating them with aminopterin (AP) and 5-bromouracil (BU). The observations indicate that the AP injection inhibits the mitosis of erythroblast with the acceleration of hemoglobin synthesis and the denucleation. The bromouracil administration scarcely suppressed the mitosis and the appearance of acidophilicity of erythroblast was retarded. Data indicate that the inhibition of mitosis accelerates the specialization or somatic protein synthesis of erythroblast. The acting mechanisms of the medicaments were discussed from the characteristics of these agents as the analogue of the substances related to DNA metabolism. |
Amo Type | Article
|
出版物タイトル |
Acta Medicinae Okayama
|
発行日 | 1968-10
|
巻 | 22巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 251
|
終了ページ | 262
|
NCID | AA00041342
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
NAID |