ID | 32384 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ogata, Masana
Okayama University
|
抄録 | Protein synthesis of the liver in both normal and CCl4 intoxicatedguinea pigs has been examined in vitro by incubating liver slices with C14-glycine. It has been demonstrated that normal liver slices synthesize albumin in vitro, which in turn incorporates with Cl4-glycine and is finally liberated into the medium very rapidly. On the other hand, immunized lymph nodes, kidney, and spleen do not show any C14-glycine incorporation into albumin. The liver slices of CCl4. intoxicated animal revealed a marked decrease in C14-glycine incorporation into albumin. Observation on the subcellular fractions proved that the incorporation of C14-glycine into microsome fraction is severely arrested, and oxygen consumption of liver slices is only slightly reduced. With the observation on the liver slices incubated with DNP, the author attributes the effect of CCl4 on protein synthesis to the decreased ATP formation by the action of CCl4 as an uncoupler for oxidative phosphorylation. |
Amo Type | Article
|
出版物タイトル |
Acta Medicinae Okayama
|
発行日 | 1962-02
|
巻 | 16巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 1
|
終了ページ | 8
|
NCID | AA00041342
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資料タイプ |
学術雑誌論文
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言語 |
英語
|
論文のバージョン | publisher
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査読 |
有り
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NAID |