Studies on the relationship between the function of reticuloendothelial system and the hematopoiesis. I. Experimental studies on the RES functions using 51Cr-labelled heat-damaged iso-erythrocytes in the induced hematological disorders of mice

The following conclusions were drawn from the above data concerning the RES function to sequestrate 51Cr-labelled heat-damaged iso-erythrocytes in mice. (l) When the hematological disorders of mice were induced, the RES of the liver and spleen reacted in the same manner. (2) The RES function of the bone marrow and liver were observed to react reversely except in the case of splenectomized mice. (3) Human gamma globulin hypersensitization and chloramphenicol administrations suppressed RES function of the bone marrow and augmented that of the liver and spleen. (4) The RES function of the bone marrow was activated after splenectomy. (5) The massive human gumma globulin administration was followed by the increased RES function of the bone marrow and by the suppressed one of the liver and spleen.