ID | 31077 |
JaLCDOI | |
フルテキストURL | |
著者 |
Watanabe, Akiharu
Okayama University
Hobara, Norio
Okayama University
Nagashima, Hideo
Okayama University
|
抄録 | The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione S-transferase may catalize this conversion. Activities of the enzyme in liver with both zathioprine and 1,2-dichloro-4-nitrobenzene as substrate decreased upon carbon tetrachloride-induced hepatic injury. These results may explain an ineffectiveness of azathioprine in patients with severe hepatic damage. |
キーワード | azathioprine
6-mercaptopurine
glutathione S-transferase
rat liver
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1978-07
|
巻 | 32巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 173
|
終了ページ | 179
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
NAID |