ID | 32809 |
JaLCDOI | |
フルテキストURL | |
著者 |
Kunii, Yuko
Okayama University
Kamada, Masahiro
Okayama University
Ohtsuki, Shinichi
Okayama University
Araki, Tohru
Okayama University
Kataoka, Kohichi
Okayama University
Kageyama, Misao
Okayama University
Nakagawa, Naomi
Okayama University
Seino, Yoshiki
Okayama University
|
抄録 | This study was designed to explore whether it was possible to evaluate the severity of VSD, PDA, and ASD by measuring brain natriuretic peptide (BNP) levels. We also investigated normal BNP levels in children to provide a baseline for our study. We measured BNP levels in 253 normal children, including 11 normal neonates, and in 91 VSD patients, 29 PDA patients, and 34 ASD patients. BNP levels showed no age-related differences in normal children (the mean value: 5.3 +/- 3.8 pg/ml). In the healthy neonates, BNP levels rose from 10.4 +/- 11.9 pg/ml in cord blood to 118.8 +/- 83.2 pg/ml on day 0, then fell to 15.3 +/- 7.8 pg/ml by day 7. In VSD and PDA patients, BNP levels correlated significantly with Qp/Qs, LVEDV, and peak RVP/LVP. In ASD patients, BNP levels correlated with Qp/Qs and RVEDV. Especially, in VSD patients, as an index corresponding to 1.5-2.0 of the Qp/Qs ratio, BNP levels of 20-35 pg/ml were found to be best with regard to both sensitivity and specificity. In the healthy neonates, BNP levels changed rapidly after birth. In VSD, PDA, and ASD patients, BNP levels were well-correlated with the severity of the disease. Especially, in VSD patients, it that appears BNP levels may be useful in evaluating surgical indications, with 20-35 pg/ml levels being the appropriate cut-off value. |
キーワード | brain natriuretic peptide
congenital heart disease
ventricular volume overload
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
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発行日 | 2003-08
|
巻 | 57巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 191
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終了ページ | 197
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |