ID | 61438 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yoshio, Kotaro
Department of Radiology, Kagawa Prefectural Central Hospital
Nagasaka, Hisako
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hisazumi, Kento
Department of Radiology, Kagawa Prefectural Central Hospital
Okawa, Hiro
Department of Radiology, Kagawa Prefectural Central Hospital
Tajiri, Nobuhisa
Department of Radiology, Kagawa Prefectural Central Hospital
Shiode, Tsuyoki
Department of Radiology, Kagawa Prefectural Central Hospital
Akaki, Shiro
Department of Radiology, Kagawa Prefectural Central Hospital
Mitoma, Tomohiro
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Yano, Yuri
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Kobayashi, Emiko
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Horiguchi, Ikuyo
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Takata, Masayo
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hongo, Atsushi
Department of Obstetrics and Gynecology 2, Kawasaki Medical School, General medical Center
Kaken ID
publons
researchmap
Yonezawa, Masaru
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Nakanishi, Yoshie
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
|
抄録 | The purposes of this retrospective study were to analyze local control of squamous cell carcinoma of the cervix treated with computed tomography (CT)-based image-guided brachytherapy (IGBT), as well as the factors affecting local control. A total of 39 patients were analyzed. The prescribed dose to the pelvis was 45-50 Gy with or without central shielding (CS). IGBT was delivered in 1-5 fractions. The total dose for high-risk clinical target volume (HR-CTV) was calculated as the biologically equivalent dose in 2-Gy fractions. The median follow-up period was 29.3 months. The 2-year overall survival and local control rates were 97% and 91%, respectively. In univariate analysis, the dose covering 90% of the HR-CTV (D90) and tumor size were found to be significant factors for local control. The cutoff values of tumor size and D90 for local control were 4.3 cm (area under the curve [AUC] 0.75) and 67.7 Gy (AUC 0.84) in the CS group and 5.3 cm (AUC 0.75) and 73.7 Gy (AUC 0.78) in the group without CS, respectively. However, though the local control of CT-based IGBT was favorable, the results suggested that the dose required for tumor control may differ depending on the presence of CS.
|
キーワード | cervical cancer
squamous cell cancer
brachytherapy
central shielding
|
Amo Type | Original Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2021-02
|
巻 | 75巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 79
|
終了ページ | 85
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
著作権者 | CopyrightⒸ 2021 by Okayama University Medical School
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID |