ID | 50409 |
JaLCDOI | |
フルテキストURL | |
著者 |
Shien, Tadahiko
Department of Breast and Endocrine Surgery, Okayama University Hospital
ORCID
Kaken ID
publons
researchmap
Kinoshita, Takayuki
Department of Surgical Oncology, National Cancer Center Hospital
Seki, Kunihiko
Department of Pathology, National Cancer Center Hospital
Yoshida, Miwa
Department of Surgical Oncology, National Cancer Center Hospital
Hojo, Takashi
Department of Surgical Oncology, National Cancer Center Hospital
Shimizu, Chikako
Department of Medical Oncology, National Cancer Center Hospital
Taira, Naruto
Department of Breast and Endocrine Surgery, Okayama University Hospital
Kaken ID
publons
Doihara, Hiroyoshi
Department of Breast and Endocrine Surgery, Okayama University Hospital
Kaken ID
researchmap
Akashi-Tanaka, Sadako
Department of Surgical Oncology, National Cancer Center Hospital
Tsuda, Hitoshi
Department of Pathology, National Cancer Center Hospital
Fujiwara, Yasuhiro
Department of Medical Oncology, National Cancer Center Hospital
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抄録 | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p=0.045) and histological grade 3 (p=0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
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キーワード | breast cancer
neoadjuvant chemotherapy
predictors
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2013-06
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巻 | 67巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 165
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終了ページ | 170
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2013 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |