ID | 65714 |
フルテキストURL | |
著者 |
Iwata, Shusuke
Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University
Yoshida, Ryusuke
Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
Takai, Shingo
Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University
Sanematsu, Keisuke
Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University
Shigemura, Noriatsu
Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University
Ninomiya, Yuzo
Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
|
抄録 | On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium-glucose cotransporter (SGLT1) and the K-ATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake.
|
キーワード | taste
sweet taste
taste receptor family 1 members 2 and 3
sodium-glucose cotransporter 1
adrenomedullin
caloric sensing
|
発行日 | 2023-06-28
|
出版物タイトル |
Nutrients
|
巻 | 15巻
|
号 | 13号
|
出版者 | MDPI
|
開始ページ | 2941
|
ISSN | 2072-6643
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2023 by the authors.
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/nu15132941
|
ライセンス | https://creativecommons.org/licenses/by/4.0/
|
Citation | Iwata, S.; Yoshida, R.; Takai, S.; Sanematsu, K.; Shigemura, N.; Ninomiya, Y. Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway. Nutrients 2023, 15, 2941. https://doi.org/10.3390/nu15132941
|
助成機関名 |
Japan Society for the Promotion of Science
|
助成番号 | JP18K17016
JP21K19601
JP18H02968
|