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ID 52866
フルテキストURL
著者
Hanaya, Tadashi Okayama Univ, Fac Sci, Dept Chem
Yamamoto, Hiroshi Shujitsu Univ, Sch Pharm
抄録
The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2-oxopropionate (12), followed by the protection of the pteridine ring. Glycosylation of 16 with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (18) in the presence of tin(IV) chloride yielded the corresponding beta-D-ribofuranoside. Successive removal of the protecting groups of the resulting D-ribofuranoside provided asperopterin A (4b).
キーワード
asperopterin
glycosylation
isoxanthopterin
protecting groups
pterin glycoside
備考
“The final publication is available at www.degruyter.com”.
発行日
2013-06
出版物タイトル
Pteridines
24巻
1号
出版者
International Society of Pteridinology
開始ページ
3
終了ページ
6
ISSN
0933-4807
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© International Society of Pteridinology
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT