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ID 44363
フルテキストURL
著者
Hanaya, Tadashi Department of Chemistry, Faculty of Science, Okayama University
Hattori, Takafumi Department of Chemistry, Faculty of Science, Okayama University
Takayama, Daisuke Department of Chemistry, Faculty of Science, Okayama University
Yamamoto, Hiroshi School of Pharmacy, Shujitsu University
抄録
1',2'-Di-O-acetyl-N2-(N,N-dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]neopterin (1) was prepared from neopterin in 5 steps. Glycosylation of 1 with methyl 2,3,4-tri-O-benzoyl-α-D-glucopyranosyluronate bromide in the presence of silver triflate and tetramethylurea afforded the corresponding 3'-O-(methyl β-D-glucopyranosyluronate) neopterin derivative (2) in 64% yield. The first synthesis of 3'-O-(β-D-glucopyranosyluronic acid)neopterin was achieved by successive removal (4 steps) of the protecting groups of 2.
キーワード
neopterin glycoside
D-glucronic acid
glycosylation
protecting groups
発行日
2010-09
出版物タイトル
Pteridines
21巻
3号
出版者
International Society of Pteridinology
開始ページ
79
終了ページ
83
ISSN
0933-4807
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.pteridines.sk/center.php?act=V&volId=140
言語
English
著作権者
Copyright © International Society of Pteridinology
論文のバージョン
publisher
査読
有り
Web of Sience KeyUT