ID | 60467 |
フルテキストURL | |
著者 |
Yoshida, Satoru
Department of Regenerative Medicine and Stem Cell Biology, Fujita Health University School of Medicine
Okura, Hanayuki
Department of Regenerative Medicine Support Promotion Facility, Center for Research Promotion and Support, Fujita Health University
Suga, Hidetaka
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Soen, Mika
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Kawaguchi, Yohei
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Kurimoto, Junki
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Miyata, Takashi
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Takagi, Hiroshi
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Arima, Hiroshi
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine
Fujikawa, Tatsuya
Department of General Internal Medicine, Mitoyo General Hospital
Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry Pharmaceutical Sciences
ORCID
Kaken ID
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Matsuyama, Akifumi
Department of Regenerative Medicine and Stem Cell Biology, Fujita Health University School of Medicine
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抄録 | Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived from peripheral blood mononuclear cells of two affected individuals in a family affected by familial neurohypophyseal diabetes insipidus carrying the c.314G>C mutation. The expression of pluripotency markers (NANOG, OCT4, and SOX2), maintenance of a normal karyotype, absence of episomal vectors used for iPSC generation, and presence of the original pathogenic mutation were confirmed for each iPSC line. The ability to differentiate into three germ layers was confirmed by a teratoma formation assay. These iPSC lines can help in disease recapitulation in vitro using organoids and elucidation of disease mechanisms.
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発行日 | 2020-10
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出版物タイトル |
Stem Cell Research
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巻 | 48巻
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出版者 | Elsevier
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開始ページ | 101960
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ISSN | 1873-5061
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 The Authors
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
関連URL | isVersionOf https://doi.org/10.1016/j.scr.2020.101960
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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