ID | 57644 |
フルテキストURL | |
著者 |
Shoji, Masaki
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Ueda, Masako
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Nishioka, Megumi
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Minato, Hiroki
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Seki, Masahide
Harada, Kenichi
Laboratory of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Kubo, Miwa
Laboratory of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Fukuyama, Yoshiyasu
Laboratory of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Suzuki, Yutaka
Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo
Aoyama, Eriko
Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School/Graduate School of Medicine Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Takigawa, Masaharu
Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School/Graduate School of Medicine Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Kuzuhara, Takashi
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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抄録 | Jiadifenolide has been reported to have neurotrophin-like activity in primary rat cortical neurons, and also possesses neurotrophic effects in neuronal precursor cells derived from human induced pluripotent stem cells (hiPSCs), as we have previously reported. However, the molecular mechanisms by which jiadifenolide exerts its neurotrophic effects in rat and human neurons are unknown. Thus, we aimed to investigate the molecular mechanisms and pathways by which jiadifenolide promotes neurotrophic effects. Here, we found that jiadifenolide activated cellular communication network factor (CCN) signaling pathways by up-regulating mRNA level expression of CCN genes in human neuronal cells. We also found that CCN2 (also known as connective tissue growth factor, CTGF) protein promotes neurotrophic effects through activation of the p44/42 mitogen-activated protein kinase signaling pathway. This is the first discovery which links neurotrophic activity with CCN signaling.
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キーワード | CCN signaling pathway
CCN2
Jiadifenolide
Neurotrophin
iPS
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発行日 | 2019-11-05
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出版物タイトル |
Biochemical and Biophysical Research Communications
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巻 | 519巻
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号 | 2号
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出版者 | Elsevier
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開始ページ | 309
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終了ページ | 315
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ISSN | 0006291X
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2019 The Authors. Published by Elsevier Inc.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.bbrc.2019.09.003
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ライセンス | http://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Shoji M, Ueda M, Nishioka M, et al. Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells. Biochem Biophys Res Commun. 2019;519(2):309‐315. doi:10.1016/j.bbrc.2019.09.003
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助成機関名 |
日本学術振興会
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助成番号 | 18K06645
19H03817
26860083
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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