ID | 58670 |
フルテキストURL | |
著者 |
Ueda, Yayoi
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tokumasu, Kazuki
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
publons
researchmap
Hagiya, Hideharu
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
researchmap
Iio, Koji
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Fujimori, Takumi
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Kakehi, Ayaka
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Okura, Mami
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Minabe, Hiroshi
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Otsuka, Fumio
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
|
抄録 | Mycobacterium chelonae is a rapidly growing mycobacterium that has the potential to cause refractory infections in humans. Mycobacteremia resulting from the organism is extremely rare, and its clinical features are yet to be uncovered. We herein present a case of M. chelonae bloodstream infection involving an immunocompromised older patient. A 79-year-old woman, on a long-term treatment with prednisolone plus tacrolimus for rheumatoid arthritis, visited our outpatient department complaining of deteriorating pain and swelling at her right 1st toe. Laboratory parameters showed elevated C-reactive protein and leukocytosis, and magnetic resonance imaging indicated osteomyelitis at the proximal phalanx of her right 1st toe. Considering the refractory course, the infected toe was immediately amputated. M. chelonae was isolated from bacterial cultures of the resected tissue and blood (BD BACTEC™ FX blood culture system, Becton Dickinson, Sparks, MD, USA), leading to a diagnosis of disseminated M. chelonae infection. We treated the patient with an antibiotic combination of clarithromycin, minocycline, and imipenem (2 weeks), which was converted to oral therapy of clarithromycin, doxycycline, and levofloxacin. This case highlighted the potential pathogenesis of M. chelonae to cause mycobacteremia in an immunocompromised patient.
|
キーワード | Mycobacterium chelonae
Mycobacteremia
Non-tuberculous mycobacteria
Osteomyelitis
Rapidly growing mycobacteria
Rheumatoid arthritis
|
備考 | This fulltext is available in May 2021.
|
発行日 | 2020-05-11
|
出版物タイトル |
Journal of Infection and Chemotherapy
|
巻 | 26巻
|
号 | 8号
|
出版者 | Elsevier
|
開始ページ | 843
|
終了ページ | 846
|
ISSN | 1341321X
|
NCID | AA11057978
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
|
論文のバージョン | author
|
PubMed ID | |
DOI | |
関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2020.03.004
|