ID | 61838 |
フルテキストURL | |
著者 |
Lan, Tien-Li
Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital
Chang, Feng-Chi
Department of Radiology, Taipei Veterans General Hospital
Wang, Chun-Wei
Division of Radiotherapy, Department of Oncology, Taiwan University Hospital
Wu, Szu-Hsien
Division of Plastic and Reconstructive Surgery, Taipei Veterans General Hospital
Lo, Wen-Liang
Division of Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Veterans General Hospital
Chen, Yi-Wei
Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital
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抄録 | Background/purpose
The incidence rate of oral and pharyngeal cancers in Taiwan has increased gradually over the past few decades. The standard treatment strategy for oral and pharyngeal cancers includes surgery or radiotherapy, with concurrent chemotherapy in certain types of tumors. Unfortunately, in-field recurrence is sometimes inexorable. Furthermore, re-irradiation of the recurrence site may cause severe complications due to the tolerance of normal tissue to radiation therapy. One fatal complication is carotid blowout syndrome (CBS). Boron neutron capture therapy (BNCT) is a new modality of radiation therapy, which is also mentioned as targeted radiotherapy. It is a feasible treatment that has the potential to spare normal tissue from being damaged by irradiation while simultaneously treating the primary tumor. In this presentation, we will share our experience with BNCT in treating recurrent head and neck cancers, as well as the prevention and management of CBS. Materials and methods We evaluated 4 patients with head and neck cancers treated by BNCT in Taiwan. All patients had undergone surgery previously and had received postoperative concurrent chemoradiotherapy. Results The 4 patients in this study were diagnosed with head and neck malignancies. The median follow-up period after the first course of BNCT was 15.1 months. After BNCT, 2 patients developed impending CBS, and 1 of them died. The remaining 3 patients survived until the last date of follow-up. Conclusion Pre-BNCT carotid artery evaluation through computed tomography angiography and early intervention if necessary is crucial when treating patients with recurrent head and neck cancers by BNCT. |
キーワード | Boron neutron capture therapy
Carotid blowout syndrome
Head and neck cancerQuality of life
Recurrence
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発行日 | 2021-01-07
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出版物タイトル |
Journal of Dental Sciences
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出版者 | Elsevier
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ISSN | 19917902
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2021 Association for Dental Sciences of the Republic of China.
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論文のバージョン | publisher
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NAID | |
DOI | |
関連URL | isVersionOf https://doi.org/10.1016/j.jds.2020.12.013
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ライセンス | http://creativecommons.org/licenses/by-nc-nd/4.0/
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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