ID | 61507 |
フルテキストURL | |
著者 |
Yoshida, Ryusuke
Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
Yasumatsu, Keiko
Tokyo Dental Junior College
Ninomiya, Yuzo
Division of Sensory Physiology and Medical Application Sensing, Research and Development Center for Five-Sense Devices, Kyushu University
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抄録 | Sugar detection in the oral cavity does not solely depend on the TAS1R2 + TAS1R3 sweet receptor. Similar to gut, pancreas, and hypothalamic neurons, in the tongue glucose transporters and ATP-sensitive K+ (KATP) channels are also involved in sugar detection. Among them, the KATP channel is the target for the antiobesity hormone leptin, which inhibits sugar-sensitive cells such as sweet taste cells, pancreatic β-cells, and hypothalamic orexigenic neurons. Sugar signals from the taste organ elicit cephalic-phase insulin release, and those from the gut contribute to sweet preference for caloric sugars. All of these systems are indispensable for maintaining energy homeostasis. Thus, an exquisite system for sugar detection/signaling to regulate energy homeostasis exists in our body.
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キーワード | gustatory nerve fibers
leptin
cephalic-phase insulin release
sweet taste
food intake
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備考 | © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0
License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.cophys.2021.01.009] .
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発行日 | 2021-04
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出版物タイトル |
Current Opinion in Physiology
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巻 | 20巻
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出版者 | Elsevier
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開始ページ | 57
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終了ページ | 63
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ISSN | 2468-8673
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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DOI | |
関連URL | isVersionOf https://doi.org/10.1016/j.cophys.2021.01.009
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/
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