ID | 57583 |
フルテキストURL | |
著者 |
Makihara, Seiichiro
Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Kariya, Shin
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Noujima-Harada, Mai
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Ohara, Nobuya
Department of Pathology, Kagawa Rosai Hospital
Naito, Tomoyuki
Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Matsumoto, Junya
Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Noda, Yohei
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okano, Mitsuhiro
Department of Otolaryngology, International University of Health and Welfare School of Medicine
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
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Nishizaki, Kazunori
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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抄録 | As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases. From these results, patients with pulmonary nodules and cervical lymphadenopathy should be examined for head and neck malignant tumors. Also, physicians should carefully check the administration of MTX. In patients with an MTX-associated LPD, we need to make an early diagnosis and consider discontinuing the administration of MTX as soon as possible.
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キーワード | MTX-associated LPD
Methotrexate
Pulmonary nodules
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備考 | This fulltext will be available in Aug 2020
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発行日 | 2019-12-31
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出版物タイトル |
Auris Nasus Larynx
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巻 | 46巻
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号 | 6号
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出版者 | Elsevier
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開始ページ | 927
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終了ページ | 933
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ISSN | 03858146
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NCID | AA00061157
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2019 Elsevier B.V. All rights reserved.
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論文のバージョン | author
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DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.anl.2019.01.010
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Citation | Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki, Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy, Auris Nasus Larynx, Volume 46, Issue 6, 2019, Pages 927-933, ISSN 0385-8146, https://doi.org/10.1016/j.anl.2019.01.010.
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助成機関名 |
文部科学省
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助成番号 | JP16K20249
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オープンアクセス(出版社) |
非OA
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オープンアーカイブ(出版社) |
非OpenArchive
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