ID | 46942 |
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著者 |
Momota, Ryusuke
Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Naito, Ichiro
Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ninomiya, Yoshifumi
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
Ohtsuka, Aiji
Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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抄録 | Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piggyBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo.
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キーワード | Extracellular matrix
Basement membrane
Collagen
Proteoglycan
Chondroitin sulfate
Wingless/Wnt
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発行日 | 2011-05
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出版物タイトル |
Matrix Biology
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巻 | 30巻
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号 | 4号
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出版者 | Elsevier Science BV
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開始ページ | 258
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終了ページ | 266
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ISSN | 0945-053X
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NCID | AA10996308
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | © 2011 Elsevier B.V. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
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