ID | 63766 |
フルテキストURL | |
著者 |
Fujimori, Takumi
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Hagiya, Hideharu
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kaken ID
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Iio, Koji
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Higashionna, Tsukasa
Department of Pharmacy, Okayama University Hospital
Kakehi, Ayaka
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Okura, Mami
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Minabe, Hiroshi
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Yokoyama, Yukika
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
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Higashikage, Akihito
Microbiology Division, Clinical Laboratory, Okayama University Hospital
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抄録 | Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of nosocomial and community infections, and vancomycin (VCM) is widely recommended as a first-line therapeutic drug. Minimum inhibitory concentrations (MICs) of VCM <2 mu g/mL are defined as susceptible, but increases in these levels, known as "VCM MIC creep" have been reported. The aim of this study was to investigate VCM MIC creep during the promotion of a national antimicrobial stewardship campaign.
Methods: We collected data from 2013 to 2020 on S. aureus isolated at the clinical microbiology laboratory at Okayama University Hospital, Japan. We calculated the annual proportions of MRSA isolation rates by MIC levels for nosocomial and community samples and estimated annual percentage changes in the antimicrobial use density of the VCM. Results: Of the 1,716 MRSA isolates, no strains showed intermediate or resistant ranges of VCM MIC levels. By 2020, the proportion of MRSA with an MIC of <0.5 mu g/mL decreased to 35.4%, while that with an MIC of 1 mu g/ mL increased to 64.1% over time. The annual percentage changes of the VCM antimicrobial use density significantly increased without any trend change point (average 8.1%, p = 0.035). There was no clear correlation between the VCM AUD and annual proportion of nosocomial MRSA with MIC 1 mu g/mL (correlation coefficient 0.48; p value = 0.24). Conclusion: We demonstrated a deteriorating situation of VCM MIC creep among MRSA strains isolated at our university hospital during the national antimicrobial stewardship campaign. |
キーワード | Antimicrobial resistance
Methicillin-resistant Staphylococcus aureus
Vancomycin
Minimum inhibitory concentration
Creep
Antimicrobial resistance
Methicillin-resistant Staphylococcus aureus
Vancomycin
Minimum inhibitory concentration
Creep
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備考 | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.03.017] .
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発行日 | 2022-07
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出版物タイトル |
Journal of Infection and Chemotherapy
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巻 | 28巻
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号 | 7号
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出版者 | Elsevier BV
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開始ページ | 918
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終了ページ | 922
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ISSN | 1341-321X
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NCID | AA11057978
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
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論文のバージョン | author
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関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2022.03.017
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ライセンス | http://creativecommons.org/licenses/by-nc-nd/4.0/
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