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ID 53656
フルテキストURL
著者
Dansako, Hiromichi Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ueda, Youki Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Okumura, Nobuaki Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Satoh, Shinya Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sugiyama, Masaya Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine
Mizokami, Masashi Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine
Ikeda, Masanori Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry
Kato, Nobuyuki Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
抄録
During viral replication, the innate immune response is induced through the recognition of viral replication intermediates by host factor(s). One of these host factors, cyclic GMP-AMP synthetase (cGAS), was recently reported to be involved in the recognition of viral DNA derived from DNA viruses. However, it is uncertain whether cGAS is involved in the recognition of hepatitis B virus (HBV), which is a hepatotropic DNA virus. In the present study, we demonstrated that HBV genome-derived dsDNA induced the innate immune response through cGAS and its adaptor protein, STING, in human hepatoma Li23 cells expressing high levels of cGAS. In addition, we demonstrated that HBV infection induced ISG56 through the cGAS-STING signaling pathway. This signaling pathway also showed an antiviral response towards HBV through the suppression of viral assembly. From these results, we conclude that the cGAS-STING signaling pathway is required for not only the innate immune response against HBV but also the suppression of HBV assembly. The cGAS-STING signaling pathway may thus be a novel target for anti-HBV strategies.
キーワード
Antiviral response
hepatitis B virus
innate immune response
cGAS-STING signaling pathway
viral assembly
備考
This is the peer reviewed version of the following article: Hiromichi Dansako, Youki Ueda, Nobuaki Okumura, Shinya Satoh, Masaya Sugiyama, Masashi Mizokami, Masanori Ikeda and Nobuyuki Kato The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly FEBS Journal, which has been published in final form at http://dx.doi.org/10.1111/febs.13563. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
発行日
2015
出版物タイトル
The FEBS journal
出版者
Blackwell Pub.
ISSN
1742-464X
NCID
AA11998513
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1111/febs.13563
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2015 Federation of European Biochemical Societies
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