ID | 65731 |
フルテキストURL | |
著者 |
Takamori, Mitsuhito
Department of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Mitoh, Yoshihiro
Department of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
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Horie, Kengo
Department of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Egusa, Masahiko
The Center for Special Needs Dentistry, Okayama University Hospital
Miyawaki, Takuya
Department of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
Yoshida, Ryusuke
Department of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
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抄録 | Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor and sugar sensing by oral glucose transporters in the oropharyngeal region in inducing CPIR. Spontaneous oral ingestion of glucose significantly increased plasma insulin 5 min later in wild-type (C57BL/6) and T1R3-knockout mice, but intragastric infusion did not. Oral treatment of glucose transporter inhibitors phlorizin and phloretin significantly reduced CPIR after spontaneous oral ingestion. In addition, a rapid increase in plasma insulin was significantly smaller in WT mice with spontaneous oral ingestion of nonmetabolizable glucose analog than in WT mice with spontaneous oral ingestion of glucose. Taken together, the T1R3-dependent receptor is not required for CPIR, but oral glucose transporters greatly contribute to induction of CPIR by sugars.
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キーワード | Cephalic-phase insulin response
Glucose transporters
Glucose
Sweet taste receptor
Food intake
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備考 | The version of record of this article, first published in The Journal of Physiological Sciences, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12576-023-00875-3
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発行日 | 2023-07-31
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出版物タイトル |
The Journal of Physiological Sciences
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巻 | 73巻
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号 | 1号
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出版者 | BMC
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開始ページ | 16
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ISSN | 1880-6546
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2023.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1186/s12576-023-00875-3
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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Citation | Takamori, M., Mitoh, Y., Horie, K. et al. Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice. J Physiol Sci 73, 16 (2023). https://doi.org/10.1186/s12576-023-00875-3
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助成機関名 |
Japan Society for the Promotion of Science
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助成番号 | 21H03106
21K19601
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