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ID 46963
フルテキストURL
著者
Yorimitsu, Takeshi Graduate School of Natural Science and Technology, Okayama University
Kiritooshi, Naruto Graduate School of Natural Science and Technology, Okayama University
Nakagoshi, Hideki Graduate School of Natural Science and Technology, Okayama University
抄録
A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The dorsal head capsule (vertex) of adult Drosophila is divided into three morphologically distinct subdomains: ocellar, frons, and orbital. The homeobox gene orthodenticle (otd) is required for head vertex development, and mutations that reduce or abolish ad expression in the vertex primordium lead to ocelliless flies. The homeodomain-containing transcriptional repressor Engrailed (En) is also involved in ocellar specification, and the En expression is completely lost in otd mutants. However, the molecular mechanism of ocellar specification remains elusive. Here, we provide evidence that the homeobox gene defective proventriculus (dye) is a downstream effector of Otd, and also that the repressor activity of Dye is required for en activation through a relief-of-repression mechanism. Furthermore, the Dye activity is involved in repression of the frons identity in an incoherent feedforward loop of Otd and Dye.
キーワード
Drosophila
Eye
Orthodenticle
Hedgehog
Engrailed
Iroquois
発行日
2011-08-15
出版物タイトル
Developmental Biology
356巻
2号
出版者
Academic Press Inc. Elsevier Science
開始ページ
598
終了ページ
607
ISSN
0012-1606
NCID
AA00627848
資料タイプ
学術雑誌論文
言語
English
著作権者
© 2011 Elsevier Inc. All rights reserved.
論文のバージョン
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査読
有り
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PubMed ID
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